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Liu CH, Liu CJ, Su TH, et al. Hepatitis B Virus Reactivation in Patients Receiving Interferon-Free Direct-Acting Antiviral Agents for Chronic Hepatitis C Virus Infection. Open Forum Infect Dis. 2017;4(1):ofx028doi: 10.1093/ofid/ofx028.
Liu, C. H., Liu, C. J., Su, T. H., Fang, Y. J., Yang, H. C., Chen, P. J., Chen, D. S., & Kao, J. H. (2017). Hepatitis B Virus Reactivation in Patients Receiving Interferon-Free Direct-Acting Antiviral Agents for Chronic Hepatitis C Virus Infection. Open forum infectious diseases, 4(1), ofx028. https://doi.org/10.1093/ofid/ofx028
Liu, Chen-Hua, et al. "Hepatitis B Virus Reactivation in Patients Receiving Interferon-Free Direct-Acting Antiviral Agents for Chronic Hepatitis C Virus Infection." Open forum infectious diseases vol. 4,1 (2017): ofx028. doi: https://doi.org/10.1093/ofid/ofx028
Liu CH, Liu CJ, Su TH, Fang YJ, Yang HC, Chen PJ, Chen DS, Kao JH. Hepatitis B Virus Reactivation in Patients Receiving Interferon-Free Direct-Acting Antiviral Agents for Chronic Hepatitis C Virus Infection. Open Forum Infect Dis. 2017 Feb 11;4(1):ofx028. doi: 10.1093/ofid/ofx028. eCollection 2017. PMID: 28480296; PMCID: PMC5414056.
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Open Forum Infect Dis. 2017 Feb 11;4(1):ofx028. doi: 10.1093/ofid/ofx028. eCollection 2017.

Hepatitis B Virus Reactivation in Patients Receiving Interferon-Free Direct-Acting Antiviral Agents for Chronic Hepatitis C Virus Infection.

Open forum infectious diseases

Chen-Hua Liu, Chun-Jen Liu, Tung-Hung Su, Yu-Jen Fang, Hung-Chih Yang, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao

Affiliations

  1. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei.
  2. Hepatitis Research Center, National Taiwan University Hospital, Taipei.
  3. Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Douliou.
  4. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei.
  5. Department of Microbiology, National Taiwan University College of Medicine, Taipei.
  6. Genomics Research Center, Academia Sinica, Taipei, Taiwan.

PMID: 28480296 PMCID: PMC5414056 DOI: 10.1093/ofid/ofx028

Abstract

BACKGROUND: Little is known about the risk of hepatitis B virus (HBV) reactivation in patients receiving interferon (IFN)-free direct-acting antiviral agents (DAAs) for hepatitis C virus (HCV).

METHODS: Patients who were seropositive for HBV core antibody and who received IFN-free DAAs for HCV were enrolled. Hepatitis B virus reactivation was defined as reappearance of serum HBV deoxyribonucleic acid (DNA) ≥100 IU/mL in patients with baseline undetectable viral load, or ≥2 log

RESULTS: Compared with no HBV reactivation in 81 HBV surface antigen (HBsAg)-negative patients, 2 of 12 HBsAg-positive patients had HBV reactivation (0% [confidence interval {95% CI}, 0%-4.5%] vs 16.7% [95% CI, 4.7%-44.8%],

CONCLUSIONS: Hepatitis B virus reactivation is limited to HBsAg-positive patients receiving IFN-free DAAs for HCV. Higher baseline HBsAg levels are associated with HBV reactivation. The risk of ALT flares or hepatic decompensation is low in these patients.

© The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Keywords: direct-acting antiviral agent; hepatitis B virus; hepatitis C virus.

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