Display options
Share it on

Biophys Rev. 2009 Sep;1(3):149. doi: 10.1007/s12551-009-0017-4. Epub 2009 Sep 11.

Muscle myosin filaments: cores, crowns and couplings.

Biophysical reviews

John M Squire

Affiliations

  1. Muscle Contraction Group, Department of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK. [email protected].

PMID: 28509995 PMCID: PMC5418396 DOI: 10.1007/s12551-009-0017-4

Abstract

Myosin filaments in muscle, carrying the ATPase myosin heads that interact with actin filaments to produce force and movement, come in multiple varieties depending on species and functional need, but most are based on a common structural theme. The now successful journeys to solve the ultrastructures of many of these myosin filaments, at least at modest resolution, have not been without their false starts and erroneous sidetracks, but the picture now emerging is of both diversity in the rotational symmetries of different filaments and a degree of commonality in the way the myosin heads are organised in resting muscle. Some of the remaining differences may be associated with how the muscle is regulated. Several proteins in cardiac muscle myosin filaments can carry mutations associated with heart disease, so the elucidation of myosin filament structure to understand the effects of these mutations has a clear and topical clinical relevance.

Keywords: Heart disease; Muscle; Myosin filaments; Myosin heads

References

  1. J Mol Biol. 1974 Sep 15;88(2):343-8 - PubMed
  2. J Struct Biol. 2006 Aug;155(2):218-29 - PubMed
  3. J Cell Biol. 1977 Dec;75(3):990-6 - PubMed
  4. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2386-90 - PubMed
  5. Adv Protein Chem. 2005;71:89-119 - PubMed
  6. J Mol Biol. 1970 Jun 14;50(2):279-95 - PubMed
  7. J Struct Biol. 2008 Aug;163(2):117-26 - PubMed
  8. Biophys J. 2008 Mar 1;94(5):1707-18 - PubMed
  9. Am J Physiol. 1993 May;264(5 Pt 1):C1085-95 - PubMed
  10. Circ Res. 2004 May 28;94(10):1279-89 - PubMed
  11. J Mol Biol. 2009 Jan 16;385(2):423-31 - PubMed
  12. J Mol Biol. 2003 Aug 15;331(3):713-24 - PubMed
  13. J Mol Biol. 1963 Sep;7:281-308 - PubMed
  14. J Mol Biol. 2000 Apr 28;298(2):239-60 - PubMed
  15. Science. 1993 Jul 2;261(5117):50-8 - PubMed
  16. J Muscle Res Cell Motil. 1981 Mar;2(1):45-64 - PubMed
  17. Curr Opin Struct Biol. 2006 Apr;16(2):204-12 - PubMed
  18. Bioessays. 1999 Oct;21(10):813-23 - PubMed
  19. J Mol Biol. 1981 Oct 5;151(4):703-30 - PubMed
  20. J Mol Biol. 1991 Jul 5;220(1):125-32 - PubMed
  21. Biophys J. 2003 Aug;85(2):1063-79 - PubMed
  22. J Mol Biol. 1973 Jun 25;77(2):291-323 - PubMed
  23. J Mol Biol. 1986 Dec 20;192(4):831-51 - PubMed
  24. Biochemistry. 1971 Dec 7;10(25):4617-24 - PubMed
  25. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11238-43 - PubMed
  26. J Gen Physiol. 2003 Dec;122(6):761-74 - PubMed
  27. Mol Biol Cell. 2008 Aug;19(8):3234-42 - PubMed
  28. J Struct Biol. 2006 Aug;155(2):202-17 - PubMed
  29. Cell. 1998 Sep 4;94(5):559-71 - PubMed
  30. J Struct Biol. 2009 May;166(2):183-94 - PubMed
  31. J Cell Biol. 1985 Aug;101(2):402-11 - PubMed
  32. J Mol Biol. 1983 Apr 5;165(2):303-20 - PubMed
  33. J Mol Biol. 1992 Feb 5;223(3):661-71 - PubMed
  34. J Mol Biol. 1968 Jan 28;31(2):155-76 - PubMed
  35. J Mol Biol. 1972 Dec 14;72(1):125-38 - PubMed
  36. J Mol Biol. 1985 Aug 5;184(3):429-39 - PubMed
  37. Ultramicroscopy. 2000 Dec;85(4):225-34 - PubMed
  38. Nature. 1971 Oct 15;233(5320):457-62 - PubMed
  39. J Mol Biol. 1981 Dec 15;153(3):781-90 - PubMed
  40. Nature. 1979 Jan 4;277(5691):37-40 - PubMed
  41. J Mol Biol. 2008 Dec 5;384(1):60-72 - PubMed
  42. J Cell Biol. 1983 Jun;96(6):1797-802 - PubMed
  43. J Struct Biol. 1995 Nov-Dec;115(3):233-49 - PubMed
  44. J Mol Biol. 1986 Oct 5;191(3):581-5 - PubMed
  45. J Mol Biol. 1977 Jan 5;109(1):49-68 - PubMed
  46. Nature. 1953 Sep 19;172(4377):530-2 - PubMed
  47. J Muscle Res Cell Motil. 1990 Feb;11(1):1-11 - PubMed
  48. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6022-6 - PubMed
  49. Science. 1969 Jun 20;164(3886):1356-65 - PubMed
  50. J Struct Biol. 2002 Jan-Feb;137(1-2):154-63 - PubMed
  51. J Muscle Res Cell Motil. 2004;25(8):635-44 - PubMed
  52. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18360-5 - PubMed
  53. Nature. 1965 Sep 18;207(5003):1276-80 - PubMed
  54. J Mol Biol. 1997 Oct 24;273(2):440-55 - PubMed
  55. Adv Exp Med Biol. 2003;538:31-40; discussion 40-1 - PubMed
  56. J Mol Biol. 1972 Jun 14;67(1):117-49 - PubMed
  57. J Mol Biol. 1981 Sep 15;151(2):309-14 - PubMed
  58. J Mol Biol. 2008 Dec 19;384(3):615-30 - PubMed
  59. J Mol Biol. 1967 Dec 14;30(2):383-434 - PubMed
  60. J Biol Chem. 2009 May 1;284(18):12318-27 - PubMed
  61. J Struct Biol. 1996 Jan-Feb;116(1):17-24 - PubMed
  62. J Muscle Res Cell Motil. 1986 Dec;7(6):550-67 - PubMed
  63. J Mol Biol. 2008 Apr 25;378(2):387-97 - PubMed
  64. J Histochem Cytochem. 1975 Jul;23(7):543-62 - PubMed
  65. J Mol Biol. 1973 Mar 15;74(4):653-76 - PubMed
  66. Biochim Biophys Acta. 2000 Mar 17;1496(1):3-22 - PubMed
  67. J Struct Biol. 2002 Jan-Feb;137(1-2):164-75 - PubMed
  68. J Mol Biol. 2008 Dec 26;384(4):780-97 - PubMed
  69. Nat Rev Mol Cell Biol. 2003 Sep;4(9):679-89 - PubMed
  70. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4361-6 - PubMed
  71. Nature. 1954 May 22;173(4412):971-3 - PubMed
  72. Nature. 2005 Aug 25;436(7054):1195-9 - PubMed
  73. J Struct Biol. 2004 Nov;148(2):236-50 - PubMed
  74. Circ Res. 2000 Jan 7-21;86(1):51-8 - PubMed
  75. Q Rev Biophys. 2000 Nov;33(4):307-69 - PubMed
  76. J Mol Biol. 1984 Jul 15;176(4):477-93 - PubMed
  77. Science. 1993 Jul 2;261(5117):58-65 - PubMed

Publication Types

Grant support