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Valerio CM, de Almeida JS, Moreira RO, et al. Dipeptidyl peptidase-4 levels are increased and partially related to body fat distribution in patients with familial partial lipodystrophy type 2. Diabetol Metab Syndr. 2017;9:26doi: 10.1186/s13098-017-0226-0.
Valerio, C. M., de Almeida, J. S., Moreira, R. O., Aguiar, L. B. S., Siciliano, P. O., Carvalho, D. P., & Godoy-Matos, A. F. (2017). Dipeptidyl peptidase-4 levels are increased and partially related to body fat distribution in patients with familial partial lipodystrophy type 2. Diabetology & metabolic syndrome, 926. https://doi.org/10.1186/s13098-017-0226-0
Valerio, Cynthia Melissa, et al. "Dipeptidyl peptidase-4 levels are increased and partially related to body fat distribution in patients with familial partial lipodystrophy type 2." Diabetology & metabolic syndrome vol. 9 (2017): 26. doi: https://doi.org/10.1186/s13098-017-0226-0
Valerio CM, de Almeida JS, Moreira RO, Aguiar LBS, Siciliano PO, Carvalho DP, Godoy-Matos AF. Dipeptidyl peptidase-4 levels are increased and partially related to body fat distribution in patients with familial partial lipodystrophy type 2. Diabetol Metab Syndr. 2017 Apr 24;9:26. doi: 10.1186/s13098-017-0226-0. eCollection 2017. PMID: 28450900; PMCID: PMC5404683.
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Diabetol Metab Syndr. 2017 Apr 24;9:26. doi: 10.1186/s13098-017-0226-0. eCollection 2017.

Dipeptidyl peptidase-4 levels are increased and partially related to body fat distribution in patients with familial partial lipodystrophy type 2.

Diabetology & metabolic syndrome

Cynthia Melissa Valerio, Juliana Severo de Almeida, Rodrigo Oliveira Moreira, Luiza Barreto S Aguiar, Priscila O Siciliano, Denise P Carvalho, Amelio F Godoy-Matos

Affiliations

  1. Metabolism Unit, Instituto Estadual de Diabetes e Endocrinologia (IEDE), Rua Moncorvo Filho 90, Rio de Janeiro, RJ CEP 20211-340 Brazil.
  2. Endocrine Physiology Laboratory, Biophysics Institute of Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rua Carlos Chagas Filho, 373, Prédio do CCS, Ilha do Fundão, Rio de Janeiro, RJ CEP 21944-97 Brazil.

PMID: 28450900 PMCID: PMC5404683 DOI: 10.1186/s13098-017-0226-0

Abstract

BACKGROUND: Dipeptidyl peptidase-4 (DDP4) is an enzyme responsible for glucagon-like peptide-1 inactivation and plays an important role in glucose metabolism.

OBJECTIVE: The aim of this study was to evaluate DPP4 levels in patients with familial partial lipodystrophy type 2 (FPLD2) and correlate it with body fat distribution.

METHODS: Fourteen patients with FPLD2 were selected to participate in this study and matched to a healthy control group (n = 8). All participants had anthropometrical data registered. Body adiposity index (BAI) was used to evaluate fat distribution in this population. Body fat content and distribution were analyzed by dual X-ray absorptiometry (DXA). Biochemical exams, including DPP4 levels, were performed in all individuals.

RESULTS: Despite the same body mass index, lipodystrophic patients had a significant lower hip (median 92.0 vs 94.5; p = 0.028), HDL cholesterol (42.6 ± 10.4 vs 66.1 ± 16.0; p < 0.01) and BAI (24.1 ± 2.8 vs 29.0 ± 3.7; p = 0.02), suggesting that BAI was able to catch differences in fat distribution between groups. On the other hand, patients with FPLD2 presented significant higher levels of insulin (median 11.2 vs 5.3; p = 0.015), triglycerides (184.9 ± 75.4 vs 89.1 ± 51.0; p < 0.01) and DPP4 (4.89 ± 0.92 vs 3.93 ± 1.08; p = 0.04). A trend toward an inverse statistical significance was observed between DPP4 levels and BAI (r = -0.38; p = 0.072). In the lipodistrophic group, a significant correlation was found between DPP4 levels and percentage of total body fat (r = 0.86; p = 0.0025) and android fat (r = 0.78; p = 0.014).

CONCLUSIONS: Patients with FPLD2 exhibit an increase in DDP4 levels in comparison to a healthy control group. The increase in the levels of this enzyme does not seem to be related to the diagnosis of diabetes and might be associated with an increase in central fat (estimated using BAI and measured using DXA). These results might be used to reinforce the concept that DDP4 is an adipokine related to central fat distribution.

Keywords: Adipokines; Dipeptidyl peptidase-4; Lipodystrophy

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