Display options
Cite
Wu MJ, Zhang YJ, Yu H, et al. Emulsified isoflurane combined with therapeutic hypothermia improves survival and neurological outcomes in a rat model of cardiac arrest. Exp Ther Med. 2017;13(3):891-898doi: 10.3892/etm.2017.4044.
Wu, M. J., Zhang, Y. J., Yu, H., & Liu, B. (2017). Emulsified isoflurane combined with therapeutic hypothermia improves survival and neurological outcomes in a rat model of cardiac arrest. Experimental and therapeutic medicine, 13(3), 891-898. https://doi.org/10.3892/etm.2017.4044
Wu, Meng-Jun, et al. "Emulsified isoflurane combined with therapeutic hypothermia improves survival and neurological outcomes in a rat model of cardiac arrest." Experimental and therapeutic medicine vol. 13,3 (2017): 891-898. doi: https://doi.org/10.3892/etm.2017.4044
Wu MJ, Zhang YJ, Yu H, Liu B. Emulsified isoflurane combined with therapeutic hypothermia improves survival and neurological outcomes in a rat model of cardiac arrest. Exp Ther Med. 2017 Mar;13(3):891-898. doi: 10.3892/etm.2017.4044. Epub 2017 Jan 13. PMID: 28450915; PMCID: PMC5403392.
Copy Download .nbib Format: NLM
Share it on

Exp Ther Med. 2017 Mar;13(3):891-898. doi: 10.3892/etm.2017.4044. Epub 2017 Jan 13.

Emulsified isoflurane combined with therapeutic hypothermia improves survival and neurological outcomes in a rat model of cardiac arrest.

Experimental and therapeutic medicine

Meng-Jun Wu, Ya-Jie Zhang, Hai Yu, Bin Liu

Affiliations

  1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

PMID: 28450915 PMCID: PMC5403392 DOI: 10.3892/etm.2017.4044

Abstract

Emulsified isoflurane (EIso), when introduced following cardiopulmonary resuscitation (CPR), significantly improves survival and neurological outcomes in a rat model of cardiac arrest (CA). The present study aimed to examine whether EIso combined with therapeutic hypothermia (TH) confers an additive neuroprotective effect. Adult male Sprague-Dawley rats that were subjected to return of spontaneous circulation (ROSC) after a 6-min asphyxia-induced CA were randomized to five groups: Sham group, control group under normothermic conditions, EIso group (4 ml/kg for 30 min under normothermic conditions), TH group (33°C for 2 h), and EIso plus TH group. Survival conditions and neurological outcomes were evaluated at 1 day and 7 days after ROSC. Animal survival rate at 7 days after ROSC was 30.7% in the CPR group, 60% in the EIso group, 63.6% in the TH group and 72.7% in the EIso plus TH group. EIso, TH and EIso plus TH yielded significant improvements in survival rates, neural deficit score and cognitive function, and ameliorated hippocampal CA1 region cell injury and apoptosis at 1 day and 7 days after ROSC compared with the CPR group. Combined therapy of EIso and TH was superior to EIso or TH alone, suggesting that combined EIso and TH treatment results in significant improvements in survival and neurological outcomes, and was more effective than independent EIso or TH treatment.

Keywords: brain; cardiac arrest; cardiopulmonary resuscitation; emulsified isoflurane; therapeutic hypothermia

References

  1. Resuscitation. 2010 Apr;81(4):398-403 - PubMed
  2. Asian Pac J Trop Med. 2013 Dec;6(12):977-81 - PubMed
  3. Crit Care Med. 2012 Apr;40(4):1221-8 - PubMed
  4. Anesthesiology. 2014 Mar;120(3):614-25 - PubMed
  5. Life Sci. 2013 Jul 19;93(1):24-9 - PubMed
  6. Anesth Analg. 2006 Jan;102(1):129-34 - PubMed
  7. Anesth Analg. 2014 Feb;118(2):310-7 - PubMed
  8. J Am Heart Assoc. 2012 Oct;1(5):e003459 - PubMed
  9. Crit Care Med. 2006 Jul;34(7):1935-40 - PubMed
  10. Crit Care Med. 2012 Apr;40(4):1297-303 - PubMed
  11. Anesth Analg. 1996 Feb;82(2):321-6 - PubMed
  12. Crit Care Med. 2008 Aug;36(8):2296-301 - PubMed
  13. Int J Cardiol. 2011 Sep 15;151(3):333-41 - PubMed
  14. Iran Red Crescent Med J. 2014 Jul;16(7):e17497 - PubMed
  15. Med Hypotheses. 2015 Jan;84(1):20-4 - PubMed
  16. Cochrane Database Syst Rev. 2016 Feb 15;2:CD004128 - PubMed
  17. Acad Emerg Med. 2014 Mar;21(3):257-65 - PubMed
  18. Circulation. 2010 Nov 2;122(18 Suppl 3):S768-86 - PubMed
  19. Crit Care Med. 2011 Jun;39(6):1423-30 - PubMed
  20. Anesthesiology. 2004 Nov;101(5):1160-6 - PubMed
  21. Can J Anaesth. 2009 Feb;56(2):115-25 - PubMed
  22. BMC Anesthesiol. 2014 Apr 16;14:28 - PubMed
  23. J Physiol Sci. 2013 Jul;63(4):251-61 - PubMed
  24. Pediatr Res. 2013 Jan;73(1):12-7 - PubMed
  25. Circulation. 2014 Dec 9;130(24):2173-80 - PubMed
  26. Crit Care Med. 2008 Jun;36(6):1780-6 - PubMed
  27. PLoS One. 2009 Oct 26;4(10):e7588 - PubMed
  28. Anesth Analg. 2008 May;106(5):1353-9, table of contents - PubMed
  29. Clin Exp Pharmacol Physiol. 2009 Aug;36(8):776-83 - PubMed
  30. Circulation. 1996 Nov 1;94(9):2324-36 - PubMed
  31. Crit Care Med. 2014 Jan;42(1):e42-8 - PubMed
  32. N Engl J Med. 2002 Feb 21;346(8):557-63 - PubMed
  33. N Engl J Med. 2002 Feb 21;346(8):549-56 - PubMed
  34. J Surg Res. 2011 Dec;171(2):783-90 - PubMed
  35. Circulation. 2010 Nov 30;122(22):2335-48 - PubMed
  36. Crit Care Med. 2014 Feb;42(2):e106-13 - PubMed
  37. World J Emerg Med. 2014;5(4):298-305 - PubMed
  38. Brain Res. 2009 Mar 3;1258:59-64 - PubMed

Publication Types