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Salama M, Sobh M, Emam M, et al. Effect of intranasal stem cell administration on the nigrostriatal system in a mouse model of Parkinson's disease. Exp Ther Med. 2017;13(3):976-982doi: 10.3892/etm.2017.4073.
Salama, M., Sobh, M., Emam, M., Abdalla, A., Sabry, D., El-Gamal, M., Lotfy, A., El-Husseiny, M., Sobh, M., Shalash, A., & Mohamed, W. M. (2017). Effect of intranasal stem cell administration on the nigrostriatal system in a mouse model of Parkinson's disease. Experimental and therapeutic medicine, 13(3), 976-982. https://doi.org/10.3892/etm.2017.4073
Salama, Mohamed, et al. "Effect of intranasal stem cell administration on the nigrostriatal system in a mouse model of Parkinson's disease." Experimental and therapeutic medicine vol. 13,3 (2017): 976-982. doi: https://doi.org/10.3892/etm.2017.4073
Salama M, Sobh M, Emam M, Abdalla A, Sabry D, El-Gamal M, Lotfy A, El-Husseiny M, Sobh M, Shalash A, Mohamed WM. Effect of intranasal stem cell administration on the nigrostriatal system in a mouse model of Parkinson's disease. Exp Ther Med. 2017 Mar;13(3):976-982. doi: 10.3892/etm.2017.4073. Epub 2017 Jan 20. PMID: 28450929; PMCID: PMC5403256.
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Exp Ther Med. 2017 Mar;13(3):976-982. doi: 10.3892/etm.2017.4073. Epub 2017 Jan 20.

Effect of intranasal stem cell administration on the nigrostriatal system in a mouse model of Parkinson's disease.

Experimental and therapeutic medicine

Mohamed Salama, Mahmoud Sobh, Mahmoud Emam, Ahmed Abdalla, Dina Sabry, Mohamed El-Gamal, Ahmed Lotfy, Mahmoud El-Husseiny, Mohamed Sobh, Ali Shalash, Wael My Mohamed

Affiliations

  1. Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
  2. Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
  3. Urology Nephrology Center, Mansoura University, Mansoura 35516, Egypt.
  4. Neurology Department, Ain Shams Medical School, Ain Shams University, Cairo 11566, Egypt.
  5. Department of Clinical Pharmacology, Menoufia Medical School, Menoufia University, Menoufia 32811, Egypt.
  6. Department of Basic Medical Science, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, Pahang 53100, Malaysia.

PMID: 28450929 PMCID: PMC5403256 DOI: 10.3892/etm.2017.4073

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It affects the locomotor system, leading to a final severe disability through degeneration of dopaminergic neurons. Despite several therapeutic approaches used, no treatment has been proven to be effective; however, cell therapy may be a promising therapeutic method. In addition, the use of the intranasal (IN) route has been advocated for delivering various therapies to the brain. In the present study, the IN route was used for administration of mesenchymal stem cells (MSCs) in a mouse model of PD, with the aim to evaluate IN delivery as an alternative route for cell based therapy administration in PD. The PD model was developed in C57BL/6 mice using intraperitoneal rotenone administration for 60 consecutive days. MSCs were isolated from the mononuclear cell fraction of pooled bone marrow from C57BL/6 mice and incubated with micrometer-sized iron oxide (MPIO) particles. For IN administration, we used a 20 µl of 5×10

Keywords: Parkinson's disease; animal model; intranasal; stem cells

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