Display options
Cite
Liu HY, Peng HY, Hsu SL, et al. Chemical characterization and antioxidative activity of four 3-hydroxyl-3-methylglutaroyl (HMG)-substituted flavonoid glycosides from Graptopetalum paraguayense E. Walther. Bot Stud. 2015;56(1):8doi: 10.1186/s40529-015-0088-4.
Liu, H. Y., Peng, H. Y., Hsu, S. L., Jong, T. T., & Chou, S. T. (2015). Chemical characterization and antioxidative activity of four 3-hydroxyl-3-methylglutaroyl (HMG)-substituted flavonoid glycosides from Graptopetalum paraguayense E. Walther. Botanical studies, 56(1), 8. https://doi.org/10.1186/s40529-015-0088-4
Liu, Hsin-Yi, et al. "Chemical characterization and antioxidative activity of four 3-hydroxyl-3-methylglutaroyl (HMG)-substituted flavonoid glycosides from Graptopetalum paraguayense E. Walther." Botanical studies vol. 56,1 (2015): 8. doi: https://doi.org/10.1186/s40529-015-0088-4
Liu HY, Peng HY, Hsu SL, Jong TT, Chou ST. Chemical characterization and antioxidative activity of four 3-hydroxyl-3-methylglutaroyl (HMG)-substituted flavonoid glycosides from Graptopetalum paraguayense E. Walther. Bot Stud. 2015 Dec;56(1):8. doi: 10.1186/s40529-015-0088-4. Epub 2015 Apr 21. PMID: 28510817; PMCID: PMC5430333.
Copy Download .nbib Format: NLM
Share it on

Bot Stud. 2015 Dec;56(1):8. doi: 10.1186/s40529-015-0088-4. Epub 2015 Apr 21.

Chemical characterization and antioxidative activity of four 3-hydroxyl-3-methylglutaroyl (HMG)-substituted flavonoid glycosides from Graptopetalum paraguayense E. Walther.

Botanical studies

Hsin-Yi Liu, Hsin-Yi Peng, Shih-Lan Hsu, Ting-Ting Jong, Su-Tze Chou

Affiliations

  1. Department of Chemistry, National Chung Hsing University, 250 Kuo-kuang Road, Taichung, 402, Taiwan.
  2. Department of Food and Nutrition, Providence University, 200, Sec. 7, Taiwan Boulevard, Taichung, 43301, Shalu Dist, Taiwan.
  3. Department of Education and Research, Taichung Veterans General Hospital, 1650, Sec. 4, Taiwan Boulevard, Taichung City, 40705, Taiwan.
  4. Department of Chemistry, National Chung Hsing University, 250 Kuo-kuang Road, Taichung, 402, Taiwan. [email protected].
  5. Department of Food and Nutrition, Providence University, 200, Sec. 7, Taiwan Boulevard, Taichung, 43301, Shalu Dist, Taiwan. [email protected].

PMID: 28510817 PMCID: PMC5430333 DOI: 10.1186/s40529-015-0088-4

Abstract

BACKGROUND: Graptopetalum paraguayense E. Walther is a popular traditional Chinese herb and possesses several health benefits. In earlier studies, we demonstrated that G. paraguayense showed no genotoxicity and showed several biological activities. However, the constituents of G. paraguayense have not been studied yet. In this present study, we isolated and identified the constituents of the leaves of G. paraguayense E. Walther.

RESULTS: A total of seven flavonoid compounds were isolated from the methanolic extract of G. paraguayense. The four major compounds isolated were flavonoid glucoside derivatives of quercetin (1, 3) and kampferol (2, 4), each presenting a 3-hydroxyl-3-methylglutaroyl (HMG) substituent; compounds 3 and 4-the 2´´-acetyl derivatives of 1 and 2, respectively-are novel compounds isolated from nature for the first time. High-performance liquid chromatography for the quantitative analyses of the four major HMG-substituted flavonoid glycosides in G. paraguayense E. Walther were accomplished to acquire the high yields of 1-4 in the methanolic extract (4.8, 5.7, 4.3, and 2.5 mg/g, respectively). Furthermore, the antioxidant activities, including radical-scavenging, reducing power and lipid peroxidation inhibitory effects of these isolated flavonoids were also evaluated. All seven of the isolated flavonoid compounds possessed antioxdative activity.

CONCLUSIONS: In this study of the constituents of the leaves of G. paraguayense E. Walther, we isolated four major components from its methanolic extract and determined their structures to be (acetylated) HMG-substituted flavonol glycosides, which are rare in nature. All seven of the isolated compounds possessed antioxdative activity, and those flavonoid compounds may be responsible for the functional ingredients in G. paraguayense. Further investigation of their bioactivities or pharmacological activities will be continued.

Keywords: 3-hydroxyl-3-methylglutaroyl (HMG); Antioxidative activity; Flavonoid glycoside; Graptopetalum paraguayense

References

  1. J Ethnopharmacol. 2011 Mar 24;134(2):379-85 - PubMed
  2. Biosci Biotechnol Biochem. 1998 Jun;62(6):1201-4 - PubMed
  3. J Ethnopharmacol. 2012 Mar 6;140(1):91-7 - PubMed
  4. Life Sci. 2006 May 15;78(25):2872-88 - PubMed
  5. Food Chem Toxicol. 1999 Nov;37(11):1055-61 - PubMed
  6. Carbohydr Res. 2004 Mar 15;339(4):891-5 - PubMed
  7. Phytochemistry. 1994 Jul;36(5):1225-7 - PubMed
  8. J Plant Res. 2004 Apr;117(2):101-7 - PubMed
  9. Biochem Pharmacol. 1996 Oct 11;52(7):1033-9 - PubMed
  10. Eur J Clin Nutr. 1993 Nov;47(11):759-64 - PubMed
  11. Am J Chin Med. 2008;36(2):369-83 - PubMed
  12. J Sci Food Agric. 2011 May;91(7):1230-5 - PubMed
  13. J Agric Food Chem. 2000 Jun;48(6):2266-70 - PubMed
  14. Chem Phys Lipids. 1987 Nov-Dec;45(2-4):337-51 - PubMed
  15. Molecules. 2014 Nov 10;19(11):18296-316 - PubMed

Publication Types