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Hou XQ, Wang L, Wang FG, et al. Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases. Genes (Basel). 2017;8(5)doi: 10.3390/genes8050135.
Hou, X. Q., Wang, L., Wang, F. G., Zhao, X. M., & Zhang, H. T. (2017). Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases. Genes, 8(5), . https://doi.org/10.3390/genes8050135
Hou, Xue-Qin, et al. "Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases." Genes vol. 8,5 (2017). doi: https://doi.org/10.3390/genes8050135
Hou XQ, Wang L, Wang FG, Zhao XM, Zhang HT. Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases. Genes (Basel). 2017 May 06;8(5). doi: 10.3390/genes8050135. PMID: 28481269; PMCID: PMC5448009.
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Genes (Basel). 2017 May 06;8(5). doi: 10.3390/genes8050135.

Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases.

Genes

Xue-Qin Hou, Lei Wang, Fu-Gang Wang, Xiao-Min Zhao, Han-Ting Zhang

Affiliations

  1. Institute of Pharmacology, Taishan Medical University, Taian 271016, Shandong, China. [email protected].
  2. Institute of Pharmacology, Taishan Medical University, Taian 271016, Shandong, China. [email protected].
  3. Institute of Pharmacology, Taishan Medical University, Taian 271016, Shandong, China. [email protected].
  4. Institute of Pharmacology, Taishan Medical University, Taian 271016, Shandong, China. [email protected].
  5. Institute of Pharmacology, Taishan Medical University, Taian 271016, Shandong, China. [email protected].
  6. Departments of Behavioral Medicine & Psychiatry and Physiology & Pharmacology, Blanchette Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA. [email protected].

PMID: 28481269 PMCID: PMC5448009 DOI: 10.3390/genes8050135

Abstract

RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their capacity to deliver RNAi to other cells. In this review, we discuss the recent advances in studies of RNAi pathways in controlling neuronal differentiation and migration of stem cells. We also highlight the utilization of a combination of RNAi and stem cells in treatment of CNS diseases.

Keywords: RNA interference; central nervous system diseases; differentiation; miRNA pathway; stem cells

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