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Richards DA, Maruani A, Chudasama V. Antibody fragments as nanoparticle targeting ligands: a step in the right direction. Chem Sci. 2016;8(1):63-77doi: 10.1039/c6sc02403c.
Richards, D. A., Maruani, A., & Chudasama, V. (2017). Antibody fragments as nanoparticle targeting ligands: a step in the right direction. Chemical science, 8(1), 63-77. https://doi.org/10.1039/c6sc02403c
Richards, Daniel A, et al. "Antibody fragments as nanoparticle targeting ligands: a step in the right direction." Chemical science vol. 8,1 (2017): 63-77. doi: https://doi.org/10.1039/c6sc02403c
Richards DA, Maruani A, Chudasama V. Antibody fragments as nanoparticle targeting ligands: a step in the right direction. Chem Sci. 2017 Jan 01;8(1):63-77. doi: 10.1039/c6sc02403c. Epub 2016 Sep 16. PMID: 28451149; PMCID: PMC5304706.
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Chem Sci. 2017 Jan 01;8(1):63-77. doi: 10.1039/c6sc02403c. Epub 2016 Sep 16.

Antibody fragments as nanoparticle targeting ligands: a step in the right direction.

Chemical science

Daniel A Richards, Antoine Maruani, Vijay Chudasama

Affiliations

  1. Department of Chemistry , University College London , 20 Gordon Street , London , WC1H 0AJ , UK . Email: [email protected] ; Email: [email protected] ; Tel: +44 (0)207 679 2077.

PMID: 28451149 PMCID: PMC5304706 DOI: 10.1039/c6sc02403c

Abstract

Recent advances in nanomedicine have shown that dramatic improvements in nanoparticle therapeutics and diagnostics can be achieved through the use of disease specific targeting ligands. Although immunoglobulins have successfully been employed for the generation of actively targeted nanoparticles, their use is often hampered by the suboptimal characteristics of the resulting complexes. Emerging data suggest that a switch in focus from full antibodies to antibody derived fragments could help to alleviate these problems and expand the potential of antibody-nanoparticle conjugates as biomedical tools. This review aims to highlight how antibody derived fragments have been utilised to overcome both fundamental and practical issues encountered during the design and application of antibody-targeted nanoparticles.

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