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Chem Sci. 2017 Feb 01;8(2):1601-1606. doi: 10.1039/c6sc04504a. Epub 2016 Nov 04.

Metal-free O-H/C-H difunctionalization of phenols by .

Chemical science

Dengfeng Chen, Qingyuan Feng, Yunqin Yang, Xu-Min Cai, Fei Wang, Shenlin Huang

Affiliations

  1. College of Chemical Engineering , Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals , Nanjing Forestry University , Nanjing , 210037 , P. R. China . Email: [email protected].

PMID: 28451289 PMCID: PMC5361865 DOI: 10.1039/c6sc04504a

Abstract

An environmentally benign method for C-H/O-H difunctionalization of phenols with sulfoxides under mild conditions has been developed. The reaction process is mediated by an electrophilic aromatic substitution and subsequent selective aryl or alkyl migration, involving C-S and C-O bond formations with broad substrate scope.

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