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Kunder M, Kutty AM, Lakshmaiah V, et al. Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia. J Clin Diagn Res. 2017;11(3):BC09-BC12doi: 10.7860/JCDR/2017/24181.9469.
Kunder, M., Kutty, A. M., Lakshmaiah, V., & Sheela, S. R. (2017). Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia. Journal of clinical and diagnostic research : JCDR, 11(3), BC09-BC12. https://doi.org/10.7860/JCDR/2017/24181.9469
Kunder, Mamatha, et al. "Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia." Journal of clinical and diagnostic research : JCDR vol. 11,3 (2017): BC09-BC12. doi: https://doi.org/10.7860/JCDR/2017/24181.9469
Kunder M, Kutty AM, Lakshmaiah V, Sheela SR. Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia. J Clin Diagn Res. 2017 Mar;11(3):BC09-BC12. doi: 10.7860/JCDR/2017/24181.9469. Epub 2017 Mar 01. PMID: 28511370; PMCID: PMC5427296.
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J Clin Diagn Res. 2017 Mar;11(3):BC09-BC12. doi: 10.7860/JCDR/2017/24181.9469. Epub 2017 Mar 01.

Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia.

Journal of clinical and diagnostic research : JCDR

Mamatha Kunder, Av Moideen Kutty, V Lakshmaiah, S R Sheela

Affiliations

  1. Lecturer, Department of Biochemistry, Sri Devaraj Urs Medical College, Kolar, Karnataka, India.
  2. Professor, Department of Biochemistry, Sri Devaraj Urs Medical College, Kolar, Karnataka, India.
  3. Professor, Department of Medicine, Sri Devaraj Urs Medical College, Kolar, Karnataka, India.
  4. Professor, Department of Obstetrics and Gynaecology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India.

PMID: 28511370 PMCID: PMC5427296 DOI: 10.7860/JCDR/2017/24181.9469

Abstract

INTRODUCTION: Pre-eclampsia (PE) is a common maternal syndrome characterized by severe systemic inflammatory response including neutrophil activation leading to uncontrolled activity of elastase. The excessive activity of elastase would lead to destroyal of the integrity of endothelial cells and could exacerbate the pathophysiological symptoms in PE. Thus, assessment of NE activity and its control mechanisms would be of relevance in the determination of severity of PE.

AIM: To correlate the activity of plasma NE and its endogenous inhibitors α

MATERIALS AND METHODS: A comparative study was conducted between normotensive pregnant (n=50) and pre-eclamptic (n=50) women. Serum C-Reactive Protein (CRP) was estimated by rapid latex slide and uric acid by uricase method. Plasma elastase was estimated using succinyl tri- L-alanyl-p-nitroanilide as substrate. Plasma α

RESULTS: The activity of elastase was increased significantly in severe PE (0.62±0.08) in comparison to normal (0.35±0.10) and mild pre-eclamptic subjects (0.37±0.03). The values of α

CONCLUSION: The results of the present study indicate a significantly elevated elastase activity, α

Keywords: NE- α1-AT complex; α1-antitrypsin; α2-macroglobulin

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