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Kooshyar MM, Mozafari PM, Amirchaghmaghi M, et al. A Randomized Placebo- Controlled Double Blind Clinical Trial of Quercetin in the Prevention and Treatment of Chemotherapy-Induced Oral Mucositis. J Clin Diagn Res. 2017;11(3):ZC46-ZC50doi: 10.7860/JCDR/2017/23975.9571.
Kooshyar, M. M., Mozafari, P. M., Amirchaghmaghi, M., Pakfetrat, A., Karoos, P., Mohasel, M. R., Orafai, H., & Azarian, A. A. (2017). A Randomized Placebo- Controlled Double Blind Clinical Trial of Quercetin in the Prevention and Treatment of Chemotherapy-Induced Oral Mucositis. Journal of clinical and diagnostic research : JCDR, 11(3), ZC46-ZC50. https://doi.org/10.7860/JCDR/2017/23975.9571
Kooshyar, Mohammad Mahdi, et al. "A Randomized Placebo- Controlled Double Blind Clinical Trial of Quercetin in the Prevention and Treatment of Chemotherapy-Induced Oral Mucositis." Journal of clinical and diagnostic research : JCDR vol. 11,3 (2017): ZC46-ZC50. doi: https://doi.org/10.7860/JCDR/2017/23975.9571
Kooshyar MM, Mozafari PM, Amirchaghmaghi M, Pakfetrat A, Karoos P, Mohasel MR, Orafai H, Azarian AA. A Randomized Placebo- Controlled Double Blind Clinical Trial of Quercetin in the Prevention and Treatment of Chemotherapy-Induced Oral Mucositis. J Clin Diagn Res. 2017 Mar;11(3):ZC46-ZC50. doi: 10.7860/JCDR/2017/23975.9571. Epub 2017 Mar 01. PMID: 28511508; PMCID: PMC5427434.
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J Clin Diagn Res. 2017 Mar;11(3):ZC46-ZC50. doi: 10.7860/JCDR/2017/23975.9571. Epub 2017 Mar 01.

A Randomized Placebo- Controlled Double Blind Clinical Trial of Quercetin in the Prevention and Treatment of Chemotherapy-Induced Oral Mucositis.

Journal of clinical and diagnostic research : JCDR

Mohammad Mahdi Kooshyar, Pegah Mosannen Mozafari, Maryam Amirchaghmaghi, Atessa Pakfetrat, Parisa Karoos, Mahdokht Rashed Mohasel, Hosein Orafai, Amir Abbas Azarian

Affiliations

  1. Associate Professor, Department of Hematology and Oncology, Imam Reza Hospital, Mashhad University of Medicals, Mashhad, Khorasan Razavi, Iran.
  2. Associate Professor, Department of Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
  3. Professor, Department of Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
  4. General Dentist, Hojjati Dentistry Clinic, Mashhad, Khorasan Razavi, Iran.
  5. Oral and Maxillofacial Medicine Specialist, Department of Pedodontics and Oral Medicine, North Khorasan University of Medical Sciences, Mashhad, Iran.
  6. Professor, Department of Industrial Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Khorasan Razavi, Iran.
  7. PhD Candidate of Statistics, Statistics Office, Mashhad University of Statistics, Mashhad, Iran.

PMID: 28511508 PMCID: PMC5427434 DOI: 10.7860/JCDR/2017/23975.9571

Abstract

INTRODUCTION: Oral Mucositis (OM) is a serious complication of chemotherapy that results in painful debilitating inflammation that sometimes ends in interruption of treatment.

AIM: The study evaluated the effect of quercetin (a natural flavonoid) on preventing and treating chemotherapy induced OM in patients with blood malignancies.

RESULTS: Nine out of 20 patients developed OM (three in the intervention group and six in the control group). The incidence of OM was lower in the intervention group although it was not statistically significant (p=0.189). The mean severity of OM was higher in the intervention group (2.6 vs 2). Healing time, age, gender, type of malignancy, drug type and duration of OM were not different in two groups.

CONCLUSION: The incidence of mucositis was lower in the quercetin group, but mucositis was more severe in the intervention group, which may be due to lower oral health status in the intervention group.

Keywords: Cancer; Flavonoids; Haematologic malignancies

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