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Amin AM, Sheau Chin L, Azri Mohamed Noor D, et al. The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics. Cardiol Res Pract. 2017;2017:8062796doi: 10.1155/2017/8062796.
Amin, A. M., Sheau Chin, L., Azri Mohamed Noor, D., Sk Abdul Kader, M. A., Kah Hay, Y., & Ibrahim, B. (2017). The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics. Cardiology research and practice, 20178062796. https://doi.org/10.1155/2017/8062796
Amin, Arwa M, et al. "The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics." Cardiology research and practice vol. 2017 (2017): 8062796. doi: https://doi.org/10.1155/2017/8062796
Amin AM, Sheau Chin L, Azri Mohamed Noor D, Sk Abdul Kader MA, Kah Hay Y, Ibrahim B. The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics. Cardiol Res Pract. 2017;2017:8062796. doi: 10.1155/2017/8062796. Epub 2017 Mar 21. PMID: 28421156; PMCID: PMC5379098.
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Cardiol Res Pract. 2017;2017:8062796. doi: 10.1155/2017/8062796. Epub 2017 Mar 21.

The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics.

Cardiology research and practice

Arwa M Amin, Lim Sheau Chin, Dzul Azri Mohamed Noor, Muhamad Ali Sk Abdul Kader, Yuen Kah Hay, Baharudin Ibrahim

Affiliations

  1. School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
  2. Cardiology Department, Hospital Pulau Pinang, Penang, Malaysia.

PMID: 28421156 PMCID: PMC5379098 DOI: 10.1155/2017/8062796

Abstract

Dual antiplatelet therapy of aspirin and clopidogrel is pivotal for patients undergoing percutaneous coronary intervention. However, the variable platelets reactivity response to clopidogrel may lead to outcome failure and recurrence of cardiovascular events. Although many genetic and nongenetic factors are known, great portion of clopidogrel variable platelets reactivity remain unexplained which challenges the personalization of clopidogrel therapy. Current methods for clopidogrel personalization include

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