Display options
Share it on

Front Cardiovasc Med. 2017 Apr 04;4:17. doi: 10.3389/fcvm.2017.00017. eCollection 2017.

Changes in Composition of the Gut Bacterial Microbiome after Fecal Microbiota Transplantation for Recurrent .

Frontiers in cardiovascular medicine

Kyle L Flannigan, Taylor Rajbar, Andrew Moffat, Leanna S McKenzie, Frank Dicke, Kevin Rioux, Matthew L Workentine, Thomas J Louie, Simon A Hirota, Steven C Greenway

Affiliations

  1. Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  2. Department of Immunology, Microbiology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  3. Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada.
  4. Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
  5. Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.
  6. Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada.
  7. Department of Medicine, University of Calgary, Calgary, AB, Canada.
  8. Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
  9. Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada.

PMID: 28421185 PMCID: PMC5378704 DOI: 10.3389/fcvm.2017.00017

Abstract

The microbiome is increasingly recognized as an important influence on human health and many of the comorbidities that affect patients after solid organ transplantation (SOT) have been shown to involve changes in gut bacterial populations. Thus, microbiome changes in an individual patient may have important health implications after SOT but this area remains understudied. We describe changes in the composition of the fecal microbiome from a pediatric heart transplant recipient before and >2.5 years after he underwent repeated fecal microbiota transplantation (FMT) for recurrent

Keywords: fecal microbiota transplant; heart transplantation; immunosuppression; microbiome; pediatric

References

  1. PLoS One. 2015 Apr 17;10(4):e0124483 - PubMed
  2. Nat Methods. 2013 Oct;10(10):996-8 - PubMed
  3. ISME J. 2010 Jan;4(1):17-27 - PubMed
  4. Transplantation. 2017 Jan;101(1):74-82 - PubMed
  5. J Clin Microbiol. 2013 Sep;51(9):2884-92 - PubMed
  6. J Microbiol Biotechnol. 2016 Mar;26(3):567-71 - PubMed
  7. Appl Environ Microbiol. 2007 Aug;73(16):5261-7 - PubMed
  8. Clin Gastroenterol Hepatol. 2011 Dec;9(12):1044-9 - PubMed
  9. PLoS One. 2013 Apr 22;8(4):e61217 - PubMed
  10. J Pediatr Gastroenterol Nutr. 2002 Jan;34(1):42-6 - PubMed
  11. Ann Am Thorac Soc. 2014 May;11(4):513-21 - PubMed
  12. Pediatr Res. 2016 Jul;80(1):2-6 - PubMed
  13. Appl Environ Microbiol. 2011 Jun;77(11):3846-52 - PubMed
  14. J Clin Invest. 2016 Jul 1;126(7):2736-44 - PubMed
  15. Am J Transplant. 2014 Feb;14(2):477-80 - PubMed
  16. J Infect Chemother. 2015 Apr;21(4):230-7 - PubMed
  17. Aliment Pharmacol Ther. 2016 Feb;43(4):445-57 - PubMed
  18. Am J Transplant. 2014 Jun;14(6):1236-48 - PubMed
  19. MBio. 2012 Oct 23;3(5):null - PubMed
  20. Genome Biol. 2014;15(12):550 - PubMed

Publication Types