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ACS Appl Mater Interfaces. 2017 May 17;9(19):16581-16593. doi: 10.1021/acsami.6b16513. Epub 2017 May 03.

External Magnetic Field-Enhanced Chemo-Photothermal Combination Tumor Therapy via Iron Oxide Nanoparticles.

ACS applied materials & interfaces

Xiaomeng Guo, Wei Li, Lihua Luo, Zuhua Wang, Qingpo Li, Fenfen Kong, Hanbo Zhang, Jie Yang, Chunqi Zhu, Yongzhong Du, Jian You

Affiliations

  1. College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China.

PMID: 28453245 DOI: 10.1021/acsami.6b16513

Abstract

The development of multifunctional nanoplatforms based on magnetic nanoparticles (MNPs) has attracted increasing attention. MNPs especially exhibit excellent responsiveness under the guidance of an external magnetic field (MF), resulting in tumor-specific, targeted delivery. The behavior and magnetic-targeting efficiency of MNPs largely depend on their physiochemical properties, especially the particle size; however, the optimal size range may vary across the multiple bioapplications associated with multifunctional nanoparticles. The optimal size range of nanoparticles for external MF-mediated targeted delivery has rarely been reported. In this work, we synthesized a series of monodisperse Fe

Keywords: chemotherapy; external magnetic field; iron oxide nanoparticles; magnetic responsiveness; tumor targeting

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