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Kazim SF, Chuang SC, Zhao W, et al. Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade. Front Aging Neurosci. 2017;9:71doi: 10.3389/fnagi.2017.00071.
Kazim, S. F., Chuang, S. C., Zhao, W., Wong, R. K., Bianchi, R., & Iqbal, K. (2017). Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade. Frontiers in aging neuroscience, 971. https://doi.org/10.3389/fnagi.2017.00071
Kazim, Syed F, et al. "Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade." Frontiers in aging neuroscience vol. 9 (2017): 71. doi: https://doi.org/10.3389/fnagi.2017.00071
Kazim SF, Chuang SC, Zhao W, Wong RK, Bianchi R, Iqbal K. Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade. Front Aging Neurosci. 2017 Mar 24;9:71. doi: 10.3389/fnagi.2017.00071. eCollection 2017. PMID: 28392767; PMCID: PMC5364175.
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Front Aging Neurosci. 2017 Mar 24;9:71. doi: 10.3389/fnagi.2017.00071. eCollection 2017.

Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade.

Frontiers in aging neuroscience

Syed F Kazim, Shih-Chieh Chuang, Wangfa Zhao, Robert K S Wong, Riccardo Bianchi, Khalid Iqbal

Affiliations

  1. Robert F. Furchgott Center for Neural and Behavioral Science and Department of Physiology and Pharmacology, State University of New York (SUNY) Downstate Medical CenterBrooklyn, NY, USA; Department of Neurochemistry and SUNY Downstate/NYSIBR Center for Developmental Neuroscience, New York State Institute for Basic Research (NYSIBR)Staten Island, NY, USA; Graduate Program in Neural and Behavioral Science, SUNY Downstate Medical CenterBrooklyn, NY, USA.
  2. Robert F. Furchgott Center for Neural and Behavioral Science and Department of Physiology and Pharmacology, State University of New York (SUNY) Downstate Medical Center Brooklyn, NY, USA.
  3. Department of Neurochemistry and SUNY Downstate/NYSIBR Center for Developmental Neuroscience, New York State Institute for Basic Research (NYSIBR) Staten Island, NY, USA.

PMID: 28392767 PMCID: PMC5364175 DOI: 10.3389/fnagi.2017.00071

Abstract

Cortical and hippocampal network hyperexcitability appears to be an early event in Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It remains unclear if network hyperexcitability precedes memory impairment in mouse models of AD and what are the underlying cellular mechanisms. We thus evaluated seizure susceptibility and hippocampal network hyperexcitability at ~3 weeks of age [prior to amyloid beta (Aβ) plaque deposition, neurofibrillary pathology, and cognitive impairment] in a triple transgenic mouse model of familial AD (3xTg-AD mouse) that harbors mutated human Aβ precursor protein (APP), tau and presenilin 1 (PS1) genes. Audiogenic seizures were elicited in a higher proportion of 3xTg-AD mice compared with wild type (WT) controls. Seizure susceptibility in 3xTg-AD mice was attenuated either by passive immunization with anti-human APP/Aβ antibody (6E10) or by blockade of metabotropic glutamate receptor 5 (mGluR5) with the selective antagonist, 2-methyl-6-(phenylethynyl)pyridine hydrochloride (MPEP). In

Keywords: Alzheimer’s disease; CA3; amyloid β (Aβ); amyloid β precursor protein (APP); epilepsy; hippocampus; metabotropic glutamate receptor 5 (mGluR5); seizure

References

  1. J Neurosci. 2009 Aug 12;29(32):9977-86 - PubMed
  2. J Neurosci. 2013 Feb 6;33(6):2526-40 - PubMed
  3. Neuron. 2005 Mar 3;45(5):675-88 - PubMed
  4. Nat Rev Neurosci. 2016 Dec;17 (12 ):777-792 - PubMed
  5. J Neurosci. 2009 Mar 18;29(11):3453-62 - PubMed
  6. J Neurophysiol. 2002 Oct;88(4):1625-33 - PubMed
  7. J Neurosci. 2015 Feb 25;35(8):3298-311 - PubMed
  8. Nature. 1990 Oct 25;347(6295):765-7 - PubMed
  9. Neuron. 2007 Sep 6;55(5):697-711 - PubMed
  10. Neuropharmacology. 1999 Oct;38(10 ):1493-503 - PubMed
  11. Cell. 2012 Apr 27;149(3):708-21 - PubMed
  12. Int J Clin Exp Pathol. 2009 Oct 10;3(1):56-68 - PubMed
  13. Mol Psychiatry. 2013 Apr;18(4):425-34 - PubMed
  14. Science. 1982 May 14;216(4547):745-7 - PubMed
  15. Acta Neuropathol. 2017 May;133(5):717-730 - PubMed
  16. PLoS One. 2014 Mar 12;9(3):e91203 - PubMed
  17. J Biol Chem. 2003 Dec 19;278(51):51100-7 - PubMed
  18. J Neurol Neurosurg Psychiatry. 1957 Feb;20(1):11-21 - PubMed
  19. Epilepsia. 2011 Jan;52 Suppl 1:39-46 - PubMed
  20. Neuropsychiatr Dis Treat. 2014 Sep 09;10:1693-705 - PubMed
  21. Cell Death Dis. 2016 Feb 18;7:e2100 - PubMed
  22. Neurobiol Aging. 2015 Jan;36(1):134-48 - PubMed
  23. Brain Res. 1983 Oct;287(2):139-71 - PubMed
  24. Neuron. 2002 Aug 15;35(4):625-41 - PubMed
  25. Science. 2007 May 4;316(5825):750-4 - PubMed
  26. Arch Pathol Lab Med. 2001 Apr;125(4):489-92 - PubMed
  27. Neuropharmacology. 2005 Dec;49(7):1053-66 - PubMed
  28. Neurobiol Dis. 2013 Oct;58:200-8 - PubMed
  29. Nature. 1982 Jun 24;297(5868):681-3 - PubMed
  30. J Alzheimers Dis. 2010;20(4):1009-13 - PubMed
  31. Curr Alzheimer Res. 2016;13(7):817-30 - PubMed
  32. Neuron. 2013 Jan 23;77(2):243-50 - PubMed
  33. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):E2895-903 - PubMed
  34. Epilepsy Behav. 2013 Mar;26(3):343-51 - PubMed
  35. J Neurophysiol. 1983 Feb;49(2):442-58 - PubMed
  36. Neurobiol Aging. 1995 May-Jun;16(3):271-8; discussion 278-84 - PubMed
  37. Acta Neuropathol. 1991;82(4):239-59 - PubMed
  38. Brain Res. 1981 Apr 6;210(1-2):323-33 - PubMed
  39. Neurobiol Aging. 2015 Feb;36(2):886-900 - PubMed
  40. Prog Brain Res. 2008;169:365-75 - PubMed
  41. Neuron. 2013 Sep 4;79(5):887-902 - PubMed
  42. Nat Rev Neurosci. 2011 Sep 07;12(10):585-601 - PubMed
  43. CNS Neurosci Ther. 2012 Apr;18(4):285-94 - PubMed
  44. PLoS Biol. 2007 Mar;5(3):e52 - PubMed
  45. Brain. 2010 Dec;133(Pt 12):3699-723 - PubMed
  46. Epilepsy Res. 2006 Jan;68 Suppl 1:S39-48 - PubMed
  47. Neurobiol Dis. 2014 Nov;71:110-30 - PubMed
  48. Hippocampus. 2013 Dec;23 (12 ):1246-58 - PubMed
  49. J Neurosci. 2013 Apr 17;33(16):7020-6 - PubMed
  50. J Neurochem. 2013 Apr;125(1):157-71 - PubMed
  51. Arch Neurol. 2009 Aug;66(8):992-7 - PubMed
  52. J Neurosci. 2007 May 30;27(22):5903-14 - PubMed
  53. Nat Cell Biol. 2007 Jul;9(7):755-64 - PubMed
  54. J Pharmacol Exp Ther. 1999 Jul;290(1):170-81 - PubMed
  55. Prog Brain Res. 2002;136:467-86 - PubMed
  56. Neuroscience. 2015 Feb 12;286:251-63 - PubMed
  57. Brain Res. 2010 Oct 1;1354:227-35 - PubMed
  58. Lancet. 2006 Jul 29;368(9533):387-403 - PubMed
  59. Brain. 2006 Nov;129(Pt 11):2966-76 - PubMed
  60. Arch Neurol. 2009 Nov;66(11):1385-92 - PubMed
  61. J Neurol. 2006 Feb;253(2):139-58 - PubMed
  62. J Neurosci. 2005 Aug 31;25(35):8048-55 - PubMed
  63. Sci Rep. 2016 Jan 28;6:20119 - PubMed
  64. J Neurophysiol. 1997 Jul;78(1):539-44 - PubMed
  65. Neuron. 2010 Jun 10;66(5):739-54 - PubMed
  66. J Neurophysiol. 1983 Feb;49(2):459-71 - PubMed
  67. J Biol Chem. 2007 Jun 29;282(26):18895-906 - PubMed
  68. Neurology. 2011 Apr 12;76(15):1344-52 - PubMed
  69. Neurosci Biobehav Rev. 2000 May;24(3):365-74 - PubMed
  70. J Neurosci. 1995 Dec;15(12):8039-52 - PubMed
  71. J Neurosci. 2015 Apr 15;35(15):6221-30 - PubMed
  72. PLoS One. 2010 Nov 23;5(11):e15509 - PubMed
  73. PLoS One. 2011;6(10):e26549 - PubMed
  74. Neuroimage Clin. 2015 Feb 21;7:688-98 - PubMed
  75. J Neurosci. 2014 Dec 3;34(49):16482-95 - PubMed
  76. Neurosci Lett. 2004 Sep 2;367(2):164-7 - PubMed
  77. Trends Neurosci. 2011 Oct;34(10):515-25 - PubMed
  78. Exp Neurol. 1999 May;157(1):135-41 - PubMed
  79. J Neurosci. 2011 Jan 12;31(2):725-34 - PubMed
  80. Arch Neurol. 2005 Dec;62(12):1821-30 - PubMed
  81. Neurology. 1993 Apr;43(4):779-85 - PubMed
  82. Front Mol Neurosci. 2016 Dec 15;9:147 - PubMed
  83. Neuron. 2012 May 10;74(3):467-74 - PubMed
  84. Arch Neurol. 2009 Apr;66(4):435-40 - PubMed
  85. Exp Neurol. 1983 Oct;82(1):237-40 - PubMed
  86. Brain Dev. 2005 Jun;27(4):246-52 - PubMed
  87. Behav Brain Res. 2013 Oct 1;254:73-82 - PubMed
  88. Int J Alzheimers Dis. 2010 Jul 15;2010:null - PubMed
  89. Epilepsy Curr. 2012 Sep;12(5):178-83 - PubMed
  90. Nat Rev Neurosci. 2008 Jan;9(1):65-75 - PubMed
  91. Alzheimers Dement. 2016 Sep;12(9):964-76 - PubMed
  92. Neurobiol Aging. 2003 Dec;24(8):1063-70 - PubMed
  93. J Neurochem. 2014 Jun;129(5):756-69 - PubMed
  94. Neurology. 1983 Mar;33(3):257-66 - PubMed
  95. PLoS One. 2015 Mar 13;10(3):e0119910 - PubMed
  96. J Neurophysiol. 1998 Aug;80(2):989-93 - PubMed
  97. Neuron. 2003 Jul 31;39(3):409-21 - PubMed
  98. Neuron. 2007 Sep 6;55(5):677-8 - PubMed
  99. Future Neurol. 2012 Mar 1;7(2):177-192 - PubMed
  100. Behav Brain Res. 2015 Feb 1;278:496-505 - PubMed
  101. J Neural Transm (Vienna). 2015 Apr;122(4):607-17 - PubMed
  102. Curr Alzheimer Res. 2011 Dec;8(8):818-31 - PubMed
  103. Neurosurgery. 2015 Feb;76(2):201-14; discussion 214-5 - PubMed
  104. Epilepsia. 2006 May;47(5):867-72 - PubMed
  105. J Neurosci. 2014 Mar 12;34(11):3826-40 - PubMed
  106. Neurobiol Aging. 2015 Jan;36(1):1-11 - PubMed
  107. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8740-5 - PubMed
  108. Brain. 2010 Apr;133(Pt 4):1143-54 - PubMed
  109. J Neurosci. 2011 Jan 12;31(2):700-11 - PubMed
  110. Acta Neurol Scand Suppl. 1996;165:3-12 - PubMed
  111. Front Cell Neurosci. 2015 Feb 05;9:19 - PubMed

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