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Kim JH, Lee SM, Son YK, et al. Resistive index as a predictor of renal progression in patients with moderate renal dysfunction regardless of angiotensin converting enzyme inhibitor or angiotensin receptor antagonist medication. Kidney Res Clin Pract. 2017;36(1):58-67doi: 10.23876/j.krcp.2017.36.1.58.
Kim, J. H., Lee, S. M., Son, Y. K., Kim, S. E., & An, W. S. (2017). Resistive index as a predictor of renal progression in patients with moderate renal dysfunction regardless of angiotensin converting enzyme inhibitor or angiotensin receptor antagonist medication. Kidney research and clinical practice, 36(1), 58-67. https://doi.org/10.23876/j.krcp.2017.36.1.58
Kim, Jae Hoon, et al. "Resistive index as a predictor of renal progression in patients with moderate renal dysfunction regardless of angiotensin converting enzyme inhibitor or angiotensin receptor antagonist medication." Kidney research and clinical practice vol. 36,1 (2017): 58-67. doi: https://doi.org/10.23876/j.krcp.2017.36.1.58
Kim JH, Lee SM, Son YK, Kim SE, An WS. Resistive index as a predictor of renal progression in patients with moderate renal dysfunction regardless of angiotensin converting enzyme inhibitor or angiotensin receptor antagonist medication. Kidney Res Clin Pract. 2017 Mar;36(1):58-67. doi: 10.23876/j.krcp.2017.36.1.58. Epub 2017 Mar 31. PMID: 28392998; PMCID: PMC5331976.
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Kidney Res Clin Pract. 2017 Mar;36(1):58-67. doi: 10.23876/j.krcp.2017.36.1.58. Epub 2017 Mar 31.

Resistive index as a predictor of renal progression in patients with moderate renal dysfunction regardless of angiotensin converting enzyme inhibitor or angiotensin receptor antagonist medication.

Kidney research and clinical practice

Jae Hoon Kim, Su Mi Lee, Young Ki Son, Seong Eun Kim, Won Suk An

Affiliations

  1. Department of Internal Medicine, Dong-A University, Busan, Korea.

PMID: 28392998 PMCID: PMC5331976 DOI: 10.23876/j.krcp.2017.36.1.58

Abstract

BACKGROUND: Previous studies have shown that a higher resistive index (RI) on renal duplex ultrasonography was related with renal progression and acute kidney injury, especially in patients with chronic kidney disease (CKD) using an angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor antagonist (ARB). We evaluated whether a RI value is a predictive factor for renal progression regardless of ACEI or ARB medication in patients with moderate renal dysfunction.

METHODS: We retrospectively analyzed 119 patients with moderate renal dysfunction that had been evaluated with renal duplex ultrasonography from February 2011 to April 2015. Moderate renal dysfunction was defined as a stage 3 to 4 CKD. Renal progression was defined as a doubling of the baseline serum creatinine (sCr), a decrease of baseline glomerular filtration rate by > 50%, or initiation of renal replacement therapy.

RESULTS: The mean age was 64.7 ± 11.0 years and sCr level was 2.1 ± 1.2 mg/dL. The RI ≥ 0.79 group showed a higher incidence of renal progression (

CONCLUSION: RI ≥ 0.79 on the renal duplex ultrasonography can be a helpful predictor for renal progression in patients with moderate renal dysfunction, regardless of their ACEI or ARB usage.

Keywords: Angiotensin receptor antagonists; Angiotensin-converting enzyme inhibitors; Chronic kidney disease; Doppler duplex ultrasonography

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