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Gai M, Frueh J, Tao T, et al. Polylactic acid nano- and microchamber arrays for encapsulation of small hydrophilic molecules featuring drug release via high intensity focused ultrasound. Nanoscale. 2017;9(21):7063-7070doi: 10.1039/c7nr01841j.
Gai, M., Frueh, J., Tao, T., Petrov, A. V., Petrov, V. V., Shesterikov, E. V., Tverdokhlebov, S. I., & Sukhorukov, G. B. (2017). Polylactic acid nano- and microchamber arrays for encapsulation of small hydrophilic molecules featuring drug release via high intensity focused ultrasound. Nanoscale, 9(21), 7063-7070. https://doi.org/10.1039/c7nr01841j
Gai, Meiyu, et al. "Polylactic acid nano- and microchamber arrays for encapsulation of small hydrophilic molecules featuring drug release via high intensity focused ultrasound." Nanoscale vol. 9,21 (2017): 7063-7070. doi: https://doi.org/10.1039/c7nr01841j
Gai M, Frueh J, Tao T, Petrov AV, Petrov VV, Shesterikov EV, Tverdokhlebov SI, Sukhorukov GB. Polylactic acid nano- and microchamber arrays for encapsulation of small hydrophilic molecules featuring drug release via high intensity focused ultrasound. Nanoscale. 2017 Jun 01;9(21):7063-7070. doi: 10.1039/c7nr01841j. PMID: 28513733.
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Nanoscale. 2017 Jun 01;9(21):7063-7070. doi: 10.1039/c7nr01841j.

Polylactic acid nano- and microchamber arrays for encapsulation of small hydrophilic molecules featuring drug release via high intensity focused ultrasound.

Nanoscale

Meiyu Gai, Johannes Frueh, Tianyi Tao, Arseniy V Petrov, Vladimir V Petrov, Evgeniy V Shesterikov, Sergei I Tverdokhlebov, Gleb B Sukhorukov

Affiliations

  1. Queen Mary University of London, School of Engineering and Materials Science, Mile End, Eng, 215, London E1 4NS, UK. [email protected].
  2. Micro/Nano Technology Research Centre, Harbin Institute of Technology, Yikuang Street 2, Harbin 150080, China. [email protected].
  3. Remote Controlled Theranostic Systems Lab, Educational Research Institute of Nanostructures and Biosystems, Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia.
  4. Experimental Physics Department, Tomsk Polytechnic University, 30 Lenin Avenue, 634050 Tomsk, Russia.
  5. Queen Mary University of London, School of Engineering and Materials Science, Mile End, Eng, 215, London E1 4NS, UK. [email protected] and Remote Controlled Theranostic Systems Lab, Educational Research Institute of Nanostructures and Biosystems, Saratov State University, 83 Astrakhanskaya Street, Saratov 410012, Russia and RASA center, Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk 634050, Russia.

PMID: 28513733 DOI: 10.1039/c7nr01841j

Abstract

Long term encapsulation combined with spatiotemporal release for a precisely defined quantity of small hydrophilic molecules on demand remains a challenge in various fields ranging from medical drug delivery, controlled release of catalysts to industrial anti-corrosion systems. Free-standing individually sealed polylactic acid (PLA) nano- and microchamber arrays were produced by one-step dip-coating a PDMS stamp into PLA solution for 5 s followed by drying under ambient conditions. The wall thickness of these hydrophobic nano-microchambers is tunable from 150 nm to 7 μm by varying the PLA solution concentration. Furthermore, small hydrophilic molecules were successfully in situ precipitated within individual microchambers in the course of solvent evaporation after sonicating the PLA@PDMS stamp to remove air-bubbles and to load the active substance containing solvent. The cargo capacity of single chambers was determined to be in the range of several picograms, while it amounts to several micrograms per cm

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