Display options
Cite
Wiemken TL, Kelley RR, Fernandez-Botran R, et al. Using cluster analysis of cytokines to identify patterns of inflammation in hospitalized patients with community-acquired pneumonia: a pilot study. Univ Louisville J Respir Infect. 2017;1(1):3-11doi: 10.18297/jri/vol1/iss1/1/.
Wiemken, T. L., Kelley, R. R., Fernandez-Botran, R., Mattingly, W. A., Arnold, F. W., Furmanek, S. P., Restrepo, M. I., Chalmers, J. D., Peyrani, P., Cavallazzi, R., Bordon, J., Aliberti, S., & Ramirez, J. A. (2017). Using cluster analysis of cytokines to identify patterns of inflammation in hospitalized patients with community-acquired pneumonia: a pilot study. The University of Louisville journal of respiratory infections, 1(1), 3-11. https://doi.org/10.18297/jri/vol1/iss1/1/
Wiemken, Timothy L, et al. "Using cluster analysis of cytokines to identify patterns of inflammation in hospitalized patients with community-acquired pneumonia: a pilot study." The University of Louisville journal of respiratory infections vol. 1,1 (2017): 3-11. doi: https://doi.org/10.18297/jri/vol1/iss1/1/
Wiemken TL, Kelley RR, Fernandez-Botran R, Mattingly WA, Arnold FW, Furmanek SP, Restrepo MI, Chalmers JD, Peyrani P, Cavallazzi R, Bordon J, Aliberti S, Ramirez JA. Using cluster analysis of cytokines to identify patterns of inflammation in hospitalized patients with community-acquired pneumonia: a pilot study. Univ Louisville J Respir Infect. 2017;1(1):3-11. doi: 10.18297/jri/vol1/iss1/1/. Epub 2017 Jan 30. PMID: 28393141; PMCID: PMC5382869.
Copy Download .nbib Format: NLM
Share it on

Univ Louisville J Respir Infect. 2017;1(1):3-11. doi: 10.18297/jri/vol1/iss1/1/. Epub 2017 Jan 30.

Using cluster analysis of cytokines to identify patterns of inflammation in hospitalized patients with community-acquired pneumonia: a pilot study.

The University of Louisville journal of respiratory infections

Timothy L Wiemken, Robert R Kelley, Rafael Fernandez-Botran, William A Mattingly, Forest W Arnold, Stephen P Furmanek, Marcos I Restrepo, James D Chalmers, Paula Peyrani, Rodrigo Cavallazzi, Jose Bordon, Stefano Aliberti, Julio A Ramirez

Affiliations

  1. University of Louisville Division of Infectious Diseases, Louisville, Kentucky, USA.
  2. University of Louisville Department of Pathology and Laboratory Medicine, Louisville, Kentucky, USA.
  3. Department of Pulmonary Diseases, South Texas Veterans Health Care System and University of Texas at San Antonio, San Antonio, Texas, USA.
  4. Department of Respiratory Medicine, Ninewells Hospital and Medical School, Dundee, United Kingdom.
  5. University of Louisville Division of Pulmonary, Critical Care, and Sleep Disorders Medicine, Louisville, Kentucky USA.
  6. Providence Hospital Section of Infectious Diseases, Washington DC, USA.
  7. Department of Health Sciences, University of Milano - Bicocca, Respiratory Unit, AO San Gerardo, Monza, Italy.

PMID: 28393141 PMCID: PMC5382869 DOI: 10.18297/jri/vol1/iss1/1/

Abstract

INTRODUCTION: Patients with severe community-acquired pneumonia (CAP) are believed to have an exaggerated inflammatory response to bacterial infection. Therapies aiming to modulate the inflammatory response have been largely unsuccessful, perhaps reflecting that CAP is a heterogeneous disorder that cannot be modulated by a single anti-inflammatory approach. We hypothesize that the host inflammatory response to pneumonia may be characterized by distinct cytokine patterns, which can be harnessed for personalized therapies.

METHODS: Here, we use hierarchical cluster analysis of cytokines to examine if patterns of inflammatory response in 13 hospitalized patients with CAP can be defined. This was a secondary data analysis of the Community-Acquired Pneumonia Inflammatory Study Group (CAPISG) database. The following cytokines were measured in plasma and sputum on the day of admission: interleukin (IL)-1β, IL-1 receptor antagonist (IL-1ra), IL-6, CXCL8 (IL-8), IL-10, IL-12p40, IL-17, interferon (IFN)

RESULTS: A total of thirteen patients were included in this pilot study. Cluster analysis identified distinct inflammatory response patterns of cytokines in the plasma, sputum, and the ratio of plasma to sputum.

CONCLUSIONS: Inflammatory response patterns in plasma and sputum can be identified in hospitalized patients with CAP. Characterization of the local and systemic inflammatory response may help to better discriminate patients for enrollment into clinical trials of immunomodulatory therapies.

Keywords: Cytokines; immunomodulation; inflammatory response; outcomes; pneumonia; steroids

References

  1. Clin Infect Dis. 2015 Jun 15;60(12):1760-6 - PubMed
  2. Am J Respir Crit Care Med. 2010 May 1;181(9):975-82 - PubMed
  3. Am J Respir Crit Care Med. 1996 Aug;154(2 Pt 1):308-17 - PubMed
  4. Chest. 2007 Apr;131(4):1006-12 - PubMed
  5. Clin Infect Dis. 2003 Feb 15;36(4):389-95 - PubMed
  6. Am J Respir Crit Care Med. 2011 Jun 1;183(11):1561-8 - PubMed
  7. Chest. 1993 Aug;104(2):389-92 - PubMed
  8. Crit Care Med. 2011 Aug;39(8):1871-8 - PubMed
  9. Lancet. 2011 Jun 11;377(9782):2023-30 - PubMed
  10. BMJ. 2006 Nov 11;333(7576):999 - PubMed
  11. Crit Care. 2011 Mar 15;15(2):R96 - PubMed
  12. JAMA. 2015 Feb 17;313(7):673-4 - PubMed
  13. Can Respir J. 2004 Nov-Dec;11(8):589-93 - PubMed
  14. J Infect. 2011 Sep;63(3):187-99 - PubMed
  15. Br Med J. 1972 Dec 9;4(5840):569-73 - PubMed
  16. BMJ. 2011 Apr 06;342:d1642 - PubMed
  17. Am J Respir Crit Care Med. 2005 Feb 1;171(3):242-8 - PubMed
  18. Pharmacoepidemiol Drug Saf. 2009 Aug;18(8):697-703 - PubMed
  19. Am J Med. 2008 Nov;121(11):1002-1007.e1 - PubMed
  20. Am J Respir Crit Care Med. 2004 Aug 15;170(4):440-4 - PubMed
  21. Eur Respir J. 2008 Mar;31(3):611-7 - PubMed
  22. Inflammation. 2014 Aug;37(4):1158-66 - PubMed
  23. JAMA. 2015 Feb 17;313(7):677-86 - PubMed
  24. Eur Respir J. 2006 May;27(5):1010-9 - PubMed
  25. N Engl J Med. 2008 Jan 10;358(2):111-24 - PubMed
  26. Respir Res. 2005 Jul 25;6:82 - PubMed
  27. Pharmacotherapy. 2007 Mar;27(3):325-32 - PubMed
  28. Lung. 2007 Sep-Oct;185(5):249-55 - PubMed
  29. Eur J Clin Microbiol Infect Dis. 2006 Aug;25(8):518-21 - PubMed
  30. Bull Johns Hopkins Hosp. 1956 Mar;98(3):197-215 - PubMed
  31. Lancet. 2015 Apr 18;385(9977):1511-8 - PubMed
  32. Clin Infect Dis. 2006 Jan 15;42(2):304-6 - PubMed
  33. Arch Intern Med. 2008 Oct 27;168(19):2081-7 - PubMed
  34. Sci Rep. 2015 Sep 16;5:14061 - PubMed

Publication Types

Grant support