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Arreola-Guerra JM, Morales-Buenrostro LE, Castelán N, et al. C1q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity But Low Sensitivity When Predicting Flow Crossmatch. Clin Transpl. 2015;31:285-292
Arreola-Guerra, J. M., Morales-Buenrostro, L. E., Castelán, N., de Santiago, A., Arvizu, A., Gonzalez-Tableros, N., López, M., Vilatobá, M., Granados, J., & Alberú, J. (2015). C1q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity But Low Sensitivity When Predicting Flow Crossmatch. Clinical transplants, 31285-292.
Arreola-Guerra, José M, et al. "C1q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity But Low Sensitivity When Predicting Flow Crossmatch." Clinical transplants vol. 31 (2015): 285-292.
Arreola-Guerra JM, Morales-Buenrostro LE, Castelán N, de Santiago A, Arvizu A, Gonzalez-Tableros N, López M, Vilatobá M, Granados J, Alberú J. C1q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity But Low Sensitivity When Predicting Flow Crossmatch. Clin Transpl. 2015;31:285-292. PMID: 28514590.
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Clin Transpl. 2015;31:285-292.

C1q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity But Low Sensitivity When Predicting Flow Crossmatch.

Clinical transplants

José M Arreola-Guerra, Luis E Morales-Buenrostro, Natalia Castelán, Adrián de Santiago, Adriana Arvizu, Norma Gonzalez-Tableros, Mayra López, Mario Vilatobá, Julio Granados, Josefina Alberú

Affiliations

  1. Department of Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico.
  2. Department of Nephrology-Mineral Metabolism, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico.
  3. Histocompatibility Laboratory, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico.

PMID: 28514590

Abstract

In complement dependent cytotoxicity crossmatch negative renal transplant candidates with human leukocyte antigen donor-specific antibodies (DSA), both the presence of DSA C1q+ and the dominant DSA fluorescence were significantly associated with a positive flow cytometry crossmatch (FXM+). The C1q+ assay was highly specific, but had low sensitivity when predicting FXM+, so the clinical significance of a FXM+ in the absence of DSA C1q+ remains to be clarified in future studies.

Copyright© 2016 by the Terasaki Foundation Laboratory.

Keywords: C1q; donor-specific antibodies; kidney; transplantation

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