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Xiang Y, Li F, Wang L, et al. Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC. Oncol Lett. 2017;13(4):2237-2243doi: 10.3892/ol.2017.5687.
Xiang, Y., Li, F., Wang, L., Zheng, A., Zuo, J., Li, M., Wang, Y., Xu, Y., Chen, C., Chen, S., Xiao, B., & Tao, Z. (2017). Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC. Oncology letters, 13(4), 2237-2243. https://doi.org/10.3892/ol.2017.5687
Xiang, Yinzhou, et al. "Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC." Oncology letters vol. 13,4 (2017): 2237-2243. doi: https://doi.org/10.3892/ol.2017.5687
Xiang Y, Li F, Wang L, Zheng A, Zuo J, Li M, Wang Y, Xu Y, Chen C, Chen S, Xiao B, Tao Z. Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC. Oncol Lett. 2017 Apr;13(4):2237-2243. doi: 10.3892/ol.2017.5687. Epub 2017 Feb 07. PMID: 28454386; PMCID: PMC5403261.
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Oncol Lett. 2017 Apr;13(4):2237-2243. doi: 10.3892/ol.2017.5687. Epub 2017 Feb 07.

Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.

Oncology letters

Yinzhou Xiang, Fen Li, Lei Wang, Anyuan Zheng, Jingjing Zuo, Man Li, Yongping Wang, Yong Xu, Chen Chen, Shiming Chen, Bokui Xiao, Zezhang Tao

Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
  2. Research Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

PMID: 28454386 PMCID: PMC5403261 DOI: 10.3892/ol.2017.5687

Abstract

Calpains are a family of intracellular cysteine proteases involved in various biological processes. Previously, the family was identified to have abnormal expression in several types of malignant tumor. Calpain 6 was less well known; however, it was recently identified to be involved in the carcinogenesis of certain types of malignant tumor. However, the expression of calpain 6 in head and neck squamous cell carcinoma (HNSCC) remains unclear. A total of six datasets from the Gene Expression Omnibus (GEO) was analyzed and an association between calpain 6 expression levels and HNSCC was identified, with the expression of calpain 6 observed to be significantly decreased in HNSCC (P<0.01). However, the expression of calpain 6 may vary between distinct tumor stages of HNSCC. Furthermore, calpain 6 expression was positively associated with the survival rate in patients with HNSCC (P<0.05), with increased expression of calpain 6 associated with an improved survival outcome. Calpain 6 expression was analyzed using an HNSCC tissue microarray and these results were consistent with the statistical analysis of the bioinformatics data from the GEO, indicating that calpain 6 may be a tumor suppressor protein in HNSCC.

Keywords: Gene Expression Omnibus; calpain 6; head and neck squamous cell carcinoma; tissue microarray; tumor stage

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