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Chao T, Wang H, Ho PC. Mitochondrial Control and Guidance of Cellular Activities of T Cells. Front Immunol. 2017;8:473doi: 10.3389/fimmu.2017.00473.
Chao, T., Wang, H., & Ho, P. C. (2017). Mitochondrial Control and Guidance of Cellular Activities of T Cells. Frontiers in immunology, 8473. https://doi.org/10.3389/fimmu.2017.00473
Chao, Tung, et al. "Mitochondrial Control and Guidance of Cellular Activities of T Cells." Frontiers in immunology vol. 8 (2017): 473. doi: https://doi.org/10.3389/fimmu.2017.00473
Chao T, Wang H, Ho PC. Mitochondrial Control and Guidance of Cellular Activities of T Cells. Front Immunol. 2017 Apr 24;8:473. doi: 10.3389/fimmu.2017.00473. eCollection 2017. PMID: 28484465; PMCID: PMC5401871.
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Front Immunol. 2017 Apr 24;8:473. doi: 10.3389/fimmu.2017.00473. eCollection 2017.

Mitochondrial Control and Guidance of Cellular Activities of T Cells.

Frontiers in immunology

Tung Chao, Haiping Wang, Ping-Chih Ho

Affiliations

  1. Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.
  2. Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland.

PMID: 28484465 PMCID: PMC5401871 DOI: 10.3389/fimmu.2017.00473

Abstract

Immune cells protect us against infection and cancer cells, as well as functioning during healing processes to support tissue repairing and regeneration. These behaviors require that upon stimulation from immune activation the appropriate subsets of immune cells are generated. In addition to activation-induced signaling cascades, metabolic reprogramming (profound changes in metabolic pathways) also provides a novel form of regulation to control the formation of desirable immune responses. Immune cells encounter various nutrient compositions by circulating in bloodstream and infiltrating into peripheral tissues; therefore, proper engagement of metabolic pathways is critical to fulfill the metabolic demands of immune cells. Metabolic pathways are tightly regulated mainly

Keywords: T cell; immunometabolism; macrophage; mitochondrion; oxidative metabolism

References

  1. Immunity. 2011 Dec 23;35(6):871-82 - PubMed
  2. Aging Cell. 2008 Jan;7(1):101-11 - PubMed
  3. Arthritis Rheum. 2002 Jan;46(1):175-90 - PubMed
  4. J Gerontol. 1956 Jul;11(3):298-300 - PubMed
  5. Hum Mol Genet. 2010 Dec 15;19(24):4861-70 - PubMed
  6. J Clin Invest. 2013 Mar;123(3):951-7 - PubMed
  7. Nat Immunol. 2013 Oct;14(10):1064-72 - PubMed
  8. Front Oncol. 2014 May 16;4:107 - PubMed
  9. Trends Immunol. 2015 Feb;36(2):71-80 - PubMed
  10. EMBO J. 2011 Apr 6;30(7):1238-50 - PubMed
  11. Mol Biol Cell. 2001 Aug;12(8):2245-56 - PubMed
  12. EMBO Rep. 2012 Oct;13(10):909-15 - PubMed
  13. J Signal Transduct. 2012;2012:646354 - PubMed
  14. Cell Metab. 2014 Apr 1;19(4):630-41 - PubMed
  15. J Biol Chem. 2008 May 16;283(20):13501-5 - PubMed
  16. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15803-8 - PubMed
  17. Nat Immunol. 2016 Jun;17 (6):712-20 - PubMed
  18. Invest Ophthalmol Vis Sci. 2011 Nov 07;52(12):8657-64 - PubMed
  19. J Biol Chem. 2003 Sep 19;278(38):36373-9 - PubMed
  20. Cell Metab. 2016 Jul 12;24(1):104-17 - PubMed
  21. Cell. 2016 Jun 30;166(1):63-76 - PubMed
  22. Immunity. 2012 Jan 27;36(1):68-78 - PubMed
  23. Cell. 2015 May 7;161(4):750-61 - PubMed
  24. Trends Immunol. 2012 Apr;33(4):168-73 - PubMed
  25. EMBO Rep. 2014 May;15(5):576-85 - PubMed
  26. Nat Cell Biol. 2011 May;13(5):589-98 - PubMed
  27. Mol Cell Biol. 2009 Aug;29(16):4495-507 - PubMed
  28. Ann N Y Acad Sci. 2010 Jul;1201:34-9 - PubMed
  29. Indian J Med Res. 2013 Nov;138(5):595-608 - PubMed
  30. Mol Cell. 2012 Aug 24;47(4):547-57 - PubMed
  31. J Immunol. 2002 Jul 15;169(2):1092-101 - PubMed
  32. J Cell Biol. 2016 Feb 15;212(4):379-87 - PubMed
  33. Nat Rev Immunol. 2012 Nov;12(11):749-61 - PubMed
  34. Cell. 2015 Sep 10;162(6):1217-28 - PubMed
  35. Immunity. 2016 Aug 16;45(2):374-88 - PubMed
  36. Mol Biol Cell. 2010 Apr 1;21(7):1225-36 - PubMed
  37. Nat Rev Immunol. 2016 Sep;16(9):553-65 - PubMed
  38. Sci Transl Med. 2015 Feb 11;7(274):274ra18 - PubMed
  39. Annu Rev Cell Dev Biol. 2006;22:79-99 - PubMed
  40. Nature. 2015 Feb 19;518(7539):413-6 - PubMed
  41. Arthritis Res Ther. 2011;13(5):241 - PubMed
  42. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10190-5 - PubMed
  43. Nat Commun. 2015 Mar 26;6:6692 - PubMed
  44. Immunity. 2015 Mar 17;42(3):406-17 - PubMed
  45. Cell Metab. 2016 Sep 13;24(3):485-93 - PubMed
  46. J Exp Med. 2011 Jul 4;208(7):1367-76 - PubMed
  47. Curr Top Dev Biol. 2004;59:119-44 - PubMed
  48. J Immunol. 2011 Mar 15;186(6):3299-303 - PubMed
  49. J Cell Biol. 2009 Dec 28;187(7):1023-36 - PubMed
  50. Mol Cell Biol. 2014 Mar;34(5):807-19 - PubMed
  51. Nat Rev Mol Cell Biol. 2012 Mar 07;13(4):270-6 - PubMed
  52. Antioxid Redox Signal. 2013 Apr 20;18(12):1497-534 - PubMed
  53. Nat Rev Immunol. 2015 Aug;15(8):486-99 - PubMed
  54. Mol Cell. 2006 Jul 21;23(2):207-17 - PubMed
  55. J Cell Biol. 2007 Aug 27;178(5):757-64 - PubMed
  56. J Clin Invest. 2013 Oct;123(10 ):4479-88 - PubMed
  57. Immunity. 2016 Aug 16;45(2):358-73 - PubMed
  58. EMBO Rep. 2007 Oct;8(10):939-44 - PubMed
  59. Front Immunol. 2017 Mar 09;8:247 - PubMed
  60. Trends Immunol. 2015 Apr;36(4):265-76 - PubMed
  61. Science. 2004 Jul 16;305(5682):390-2 - PubMed
  62. Science. 2012 Aug 31;337(6098):1062-5 - PubMed
  63. Cell Metab. 2017 Feb 7;25(2):345-357 - PubMed
  64. Blood. 2007 Mar 15;109(6):2505-13 - PubMed
  65. Curr Opin Cell Biol. 2003 Apr;15(2):241-6 - PubMed
  66. Immunity. 2013 Apr 18;38(4):633-43 - PubMed
  67. Cancer Res. 2004 Feb 1;64(3):985-93 - PubMed
  68. Nat Med. 2016 Feb;22(2):146-53 - PubMed
  69. Nature. 2016 Dec 8;540(7632):236-241 - PubMed
  70. Cancer Metab. 2015 Jan 25;3(1):1 - PubMed
  71. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14336-41 - PubMed
  72. J Biol Chem. 2004 Apr 30;279(18):18792-8 - PubMed

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