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Dubicanac M, Strueve J, Mestre-Frances N, et al. Photoperiodic regime influences onset of lens opacities in a non-human primate. PeerJ. 2017;5:e3258doi: 10.7717/peerj.3258.
Dubicanac, M., Strueve, J., Mestre-Frances, N., Verdier, J. M., Zimmermann, E., & Joly, M. (2017). Photoperiodic regime influences onset of lens opacities in a non-human primate. PeerJ, 5e3258. https://doi.org/10.7717/peerj.3258
Dubicanac, Marko, et al. "Photoperiodic regime influences onset of lens opacities in a non-human primate." PeerJ vol. 5 (2017): e3258. doi: https://doi.org/10.7717/peerj.3258
Dubicanac M, Strueve J, Mestre-Frances N, Verdier JM, Zimmermann E, Joly M. Photoperiodic regime influences onset of lens opacities in a non-human primate. PeerJ. 2017 May 04;5:e3258. doi: 10.7717/peerj.3258. eCollection 2017. PMID: 28484672; PMCID: PMC5420196.
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PeerJ. 2017 May 04;5:e3258. doi: 10.7717/peerj.3258. eCollection 2017.

Photoperiodic regime influences onset of lens opacities in a non-human primate.

PeerJ

Marko Dubicanac, Julia Strueve, Nadine Mestre-Frances, Jean-Michel Verdier, Elke Zimmermann, Marine Joly

Affiliations

  1. Institute of Zoology, Tierärztliche Hochschule Hannover, Hanover, Lower Saxony, Germany.
  2. Clinic for Small Animals, Tierärztliche Hochschule Hannover, Hanover, Lower Saxony, Germany.
  3. Department of Molecular Mechanisms in Neurodegenerative Diseases Inserm U1198, Univ. Montpellier, Montpellier, France.
  4. Centre for Comparative and Evolutionary Psychology, University of Portsmouth, Portsmouth, United Kingdom.

PMID: 28484672 PMCID: PMC5420196 DOI: 10.7717/peerj.3258

Abstract

BACKGROUND: Opacities of the lens are typical age-related phenomena which have a high influence on photoreception and consequently circadian rhythm. In mouse lemurs, a small bodied non-human primate, a high incidence (more than 50% when >seven years) of cataracts has been previously described during aging. Previous studies showed that photoperiodically induced accelerated annual rhythms alter some of mouse lemurs' life history traits. Whether a modification of photoperiod also affects the onset of age dependent lens opacities has not been investigated so far. The aim of this study was therefore to characterise the type of opacity and the mouse lemurs' age at its onset in two colonies with different photoperiodic regimen.

METHODS: Two of the largest mouse lemur colonies in Europe were investigated: Colony 1 having a natural annual photoperiodic regime and Colony 2 with an induced accelerated annual cycle. A slit-lamp was used to determine opacities in the lens. Furthermore, a subset of all animals which showed no opacities in the lens nucleus in the first examination but developed first changes in the following examination were further examined to estimate the age at onset of opacities. In total, 387 animals were examined and 57 represented the subset for age at onset estimation.

RESULTS: The first and most commonly observable opacity in the lens was nuclear sclerosis. Mouse lemurs from Colony 1 showed a delayed onset of nuclear sclerosis compared to mouse lemurs from Colony 2 (4.35 ± 1.50 years

DISCUSSION: Our study showed clear differences in age at the onset of nuclear sclerosis formation between lemurs kept under different photoperiodic regimes. Instead of measuring the chronological age, the number of seasonal cycles (

Keywords: Aging; Cataract; Mouse lemur; Nuclear sclerosis; Photoperiod; Primate

Conflict of interest statement

Elke Zimmermann is an Academic Editor for PeerJ.

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