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Chung Y, Kim H, Seon S, et al. Serum Cytokine Levels are related to Nesfatin-1/NUCB2 Expression in the Implantation Sites of Spontaneous Abortion Model of CBA/j × DBA/2 Mice. Dev Reprod. 2017;21(1):35-46doi: 10.12717/DR.2017.21.1.035.
Chung, Y., Kim, H., Seon, S., & Yang, H. (2017). Serum Cytokine Levels are related to Nesfatin-1/NUCB2 Expression in the Implantation Sites of Spontaneous Abortion Model of CBA/j × DBA/2 Mice. Development & reproduction, 21(1), 35-46. https://doi.org/10.12717/DR.2017.21.1.035
Chung, Yiwa, et al. "Serum Cytokine Levels are related to Nesfatin-1/NUCB2 Expression in the Implantation Sites of Spontaneous Abortion Model of CBA/j × DBA/2 Mice." Development & reproduction vol. 21,1 (2017): 35-46. doi: https://doi.org/10.12717/DR.2017.21.1.035
Chung Y, Kim H, Seon S, Yang H. Serum Cytokine Levels are related to Nesfatin-1/NUCB2 Expression in the Implantation Sites of Spontaneous Abortion Model of CBA/j × DBA/2 Mice. Dev Reprod. 2017 Mar;21(1):35-46. doi: 10.12717/DR.2017.21.1.035. Epub 2017 Mar 31. PMID: 28484742; PMCID: PMC5409208.
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Dev Reprod. 2017 Mar;21(1):35-46. doi: 10.12717/DR.2017.21.1.035. Epub 2017 Mar 31.

Serum Cytokine Levels are related to Nesfatin-1/NUCB2 Expression in the Implantation Sites of Spontaneous Abortion Model of CBA/j × DBA/2 Mice.

Development & reproduction

Yiwa Chung, Heejeong Kim, Sojeong Seon, Hyunwon Yang

Affiliations

  1. Department of Bioenvironmental Technology, College of Natural Sciences, Seoul Women's University, Seoul 01797, Korea.

PMID: 28484742 PMCID: PMC5409208 DOI: 10.12717/DR.2017.21.1.035

Abstract

The process of spontaneous abortion involves a complex mechanism with various cytokines, growth factors, and hormones during the pregnancy. However, the mechanism underlying spontaneous abortion by pro- and anti-inflammatory cytokines in the serum during the pregnancy is not fully understood. Therefore, the purpose of this study was to examine the relationship between the serum levels of pro- and anti-inflammatory cytokines and spontaneous abortion using the CBA/j × DBA/2 mouse model. Serum levels of pro-inflammatory cytokines, such as IFN-γ, IL-1α and TNF-α were not increased in abortion model mice, but anti-inflammatory cytokines, such as IL-4, IL-13 and IL-1ra were decreased compared to normal pregnant mice. In addition, serum levels of chemokine, such as SDF-1, G-CSF, M-CSF, IL-16, KC and MCP-1 were decreased in abortion model mice compared to normal pregnant mice. However, the expression levels of nesfatin-1/NUCB2 mRNA and protein in the uteri of implantation sites were significantly higher in abortion model mice than normal pregnant mice. These results suggest that uterine nesfatin-1/NUCB2 expression may be down-regulated by inflammatory cytokines and chemokines in the serum of pregnant mice. Moreover, this study suggests the possibility that nesfatin-1/NUCB2 expressed in the implantation sites may be associated with the maintenance of pregnancy.

Keywords: Chemokine; Cytokine; Nesfatin-1; Nesfatin-1/NUCB2; Spontaneous abortion

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