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Food Res Int. 2015 Oct;76:373-386. doi: 10.1016/j.foodres.2015.07.016. Epub 2015 Jul 17.

A comprehensive review on in vitro digestion of infant formula.

Food research international (Ottawa, Ont.)

Thao T P Nguyen, Bhesh Bhandari, Julie Cichero, Sangeeta Prakash

Affiliations

  1. School of Agriculture and Food Sciences, The University of Queensland, Brisbane, Australia.
  2. School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Australia.

PMID: 28455017 DOI: 10.1016/j.foodres.2015.07.016

Abstract

Although mothers' milk is the best food for babies, infant formula has become an alternative when breastfeeding is not possible or inadequate for babies. To design a proper formula for babies, understanding digestibility of macronutrients and their bio-accessibility in the gastrointestinal tract is essential. In vivo gastrointestinal studies on human infants are restricted by ethical constraint, cost issues, and intensive resource. However, in vitro models offer many advantages with low cost, easy sampling accessibility and no ethical issues. This article aims at reviewing the main aspects of the infant physiological gastrointestinal tract and providing an insight on recent in vitro research on infant formula.

Copyright © 2015 Elsevier Ltd. All rights reserved.

Keywords: Digestibility; Enzymes; Gastric; In vitro; Infant digestion; Infant formula; Intestine

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