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Song Z, Shah SZA, Yang W, et al. Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models. Front Mol Neurosci. 2017;10:128doi: 10.3389/fnmol.2017.00128.
Song, Z., Shah, S. Z. A., Yang, W., Dong, H., Yang, L., Zhou, X., & Zhao, D. (2017). Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models. Frontiers in molecular neuroscience, 10128. https://doi.org/10.3389/fnmol.2017.00128
Song, Zhiqi, et al. "Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models." Frontiers in molecular neuroscience vol. 10 (2017): 128. doi: https://doi.org/10.3389/fnmol.2017.00128
Song Z, Shah SZA, Yang W, Dong H, Yang L, Zhou X, Zhao D. Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models. Front Mol Neurosci. 2017 May 03;10:128. doi: 10.3389/fnmol.2017.00128. eCollection 2017. PMID: 28515679; PMCID: PMC5413570.
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Front Mol Neurosci. 2017 May 03;10:128. doi: 10.3389/fnmol.2017.00128. eCollection 2017.

Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models.

Frontiers in molecular neuroscience

Zhiqi Song, Syed Z A Shah, Wei Yang, Haodi Dong, Lifeng Yang, Xiangmei Zhou, Deming Zhao

Affiliations

  1. The State Key Laboratories for Agrobiotechnology, Key Lab of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural UniversityBeijing, China.

PMID: 28515679 PMCID: PMC5413570 DOI: 10.3389/fnmol.2017.00128

Abstract

Prion diseases are a group of infectious diseases characterized by multiple neuropathological changes, yet the mechanisms that preserve function and protect against prion-associated neurodegeneration are still unclear. We previously reported that the repressor element 1-silencing transcription factor (REST) alleviates neurotoxic prion peptide (PrP106-126)-induced toxicity in primary neurons. Here we confirmed the findings of the

Keywords: RE1-silencing transcription factor; neuroprotective mechanism; prion diseases; the Akt–mTOR signaling; the Wnt-β-catenin signaling

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