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Kusek M, Tokarska A, Siwiec M, et al. Nitric Oxide Synthase Inhibitor Attenuates the Effects of Repeated Restraint Stress on Synaptic Transmission in the Paraventricular Nucleus of the Rat Hypothalamus. Front Cell Neurosci. 2017;11:127doi: 10.3389/fncel.2017.00127.
Kusek, M., Tokarska, A., Siwiec, M., Gadek-Michalska, A., Szewczyk, B., Hess, G., & Tokarski, K. (2017). Nitric Oxide Synthase Inhibitor Attenuates the Effects of Repeated Restraint Stress on Synaptic Transmission in the Paraventricular Nucleus of the Rat Hypothalamus. Frontiers in cellular neuroscience, 11127. https://doi.org/10.3389/fncel.2017.00127
Kusek, Magdalena, et al. "Nitric Oxide Synthase Inhibitor Attenuates the Effects of Repeated Restraint Stress on Synaptic Transmission in the Paraventricular Nucleus of the Rat Hypothalamus." Frontiers in cellular neuroscience vol. 11 (2017): 127. doi: https://doi.org/10.3389/fncel.2017.00127
Kusek M, Tokarska A, Siwiec M, Gadek-Michalska A, Szewczyk B, Hess G, Tokarski K. Nitric Oxide Synthase Inhibitor Attenuates the Effects of Repeated Restraint Stress on Synaptic Transmission in the Paraventricular Nucleus of the Rat Hypothalamus. Front Cell Neurosci. 2017 May 03;11:127. doi: 10.3389/fncel.2017.00127. eCollection 2017. PMID: 28515682; PMCID: PMC5413825.
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Front Cell Neurosci. 2017 May 03;11:127. doi: 10.3389/fncel.2017.00127. eCollection 2017.

Nitric Oxide Synthase Inhibitor Attenuates the Effects of Repeated Restraint Stress on Synaptic Transmission in the Paraventricular Nucleus of the Rat Hypothalamus.

Frontiers in cellular neuroscience

Magdalena Kusek, Anna Tokarska, Marcin Siwiec, Anna Gadek-Michalska, Bernadeta Szewczyk, Grzegorz Hess, Krzysztof Tokarski

Affiliations

  1. Department of Physiology, Institute of Pharmacology, Polish Academy of SciencesKraków, Poland.
  2. Institute of Zoology and Biomedical Research, Jagiellonian UniversityKraków, Poland.
  3. Department of Neurobiology, Institute of Pharmacology, Polish Academy of SciencesKraków, Poland.

PMID: 28515682 PMCID: PMC5413825 DOI: 10.3389/fncel.2017.00127

Abstract

Corticotropin-releasing hormone (CRH)-synthesizing parvocellular neuroendocrine cells (PNCs) of the hypothalamic paraventricular nucleus (PVN) play a key role in the activation of the hypothalamic-pituitary-adrenocortical (HPA) axis. Several studies have demonstrated that synaptic inputs to these cells may undergo stress-related enhancement but, on the other hand, it has been reported that exposition to the same stressor for prolonged time periods may induce a progressive reduction in the response of the HPA axis to homotypic stressors. In the present study rats were subjected to 10 min restraint sessions, repeated twice daily for 3 or 7 days. Miniature excitatory and inhibitory postsynaptic currents (mEPSCs and mIPSCs) were then recorded from PNCs in

Keywords: GABAergic; HPA; PVN; corticosterone; glutamatergic; mEPSC; mIPSC; stress

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