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Escudero CA, Herlitz K, Troncoso F, et al. Pro-angiogenic Role of Insulin: From Physiology to Pathology. Front Physiol. 2017;8:204doi: 10.3389/fphys.2017.00204.
Escudero, C. A., Herlitz, K., Troncoso, F., Guevara, K., Acurio, J., Aguayo, C., Godoy, A. S., & González, M. (2017). Pro-angiogenic Role of Insulin: From Physiology to Pathology. Frontiers in physiology, 8204. https://doi.org/10.3389/fphys.2017.00204
Escudero, Carlos A, et al. "Pro-angiogenic Role of Insulin: From Physiology to Pathology." Frontiers in physiology vol. 8 (2017): 204. doi: https://doi.org/10.3389/fphys.2017.00204
Escudero CA, Herlitz K, Troncoso F, Guevara K, Acurio J, Aguayo C, Godoy AS, González M. Pro-angiogenic Role of Insulin: From Physiology to Pathology. Front Physiol. 2017 Apr 05;8:204. doi: 10.3389/fphys.2017.00204. eCollection 2017. PMID: 28424632; PMCID: PMC5380736.
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Front Physiol. 2017 Apr 05;8:204. doi: 10.3389/fphys.2017.00204. eCollection 2017.

Pro-angiogenic Role of Insulin: From Physiology to Pathology.

Frontiers in physiology

Carlos A Escudero, Kurt Herlitz, Felipe Troncoso, Katherine Guevara, Jesenia Acurio, Claudio Aguayo, Alejandro S Godoy, Marcelo González

Affiliations

  1. Group of Investigation in Tumor Angiogenesis, Vascular Physiology Laboratory, Basic Sciences Department, Universidad del Bío BíoChillán, Chile.
  2. Group of Research and Innovation in Vascular Health, Department of Basic Sciences, Universidad del Bío-BíoChillán, Chile.
  3. Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of ConcepciónConcepción, Chile.
  4. Department of Physiology, Pontificia Universidad Católica de ChileSantiago, Chile.
  5. Department of Urology, Roswell Park Cancer InstituteBuffalo, NY, USA.
  6. Vascular Physiology Laboratory, Department of Physiology, Faculty of Biological Sciences, Universidad of ConcepciónConcepción, Chile.

PMID: 28424632 PMCID: PMC5380736 DOI: 10.3389/fphys.2017.00204

Abstract

The underlying molecular mechanisms involve in the regulation of the angiogenic process by insulin are not well understood. In this review article, we aim to describe the role of insulin and insulin receptor activation on the control of angiogenesis and how these mechanisms can be deregulated in human diseases. Functional expression of insulin receptors and their signaling pathways has been described on endothelial cells and pericytes, both of the main cells involved in vessel formation and maturation. Consequently, insulin has been shown to regulate endothelial cell migration, proliferation, and

Keywords: angiogenesis; endothelial cells; insulin; insulin receptor

References

  1. Nat Rev Mol Cell Biol. 2006 Feb;7(2):85-96 - PubMed
  2. Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):787-93 - PubMed
  3. Neurobiol Aging. 2004 Jan;25(1):93-103 - PubMed
  4. N Engl J Med. 1994 Dec 1;331(22):1480-7 - PubMed
  5. Cell Metab. 2012 Dec 5;16(6):723-37 - PubMed
  6. J Clin Invest. 2002 Mar;109(6):805-15 - PubMed
  7. Endocr Rev. 2007 Aug;28(5):463-91 - PubMed
  8. Curr Diabetes Rev. 2013 Jan 1;9(1):25-53 - PubMed
  9. J Wound Care. 2008 Jan;17(1):30-2, 34-7 - PubMed
  10. Circ Res. 2005 Sep 16;97(6):512-23 - PubMed
  11. J Am Coll Cardiol. 2005 Sep 6;46(5):835-7 - PubMed
  12. Diabetologia. 2007 Feb;50(2):461-70 - PubMed
  13. Wound Repair Regen. 2014 Sep-Oct;22(5):569-78 - PubMed
  14. Cardiorenal Med. 2014 Dec;4(3-4):244-56 - PubMed
  15. Curr Diabetes Rev. 2006 Feb;2(1):71-98 - PubMed
  16. BMJ Clin Evid. 2016 Mar 16;2016:null - PubMed
  17. Curr Vasc Pharmacol. 2011 Nov;9(6):750-62 - PubMed
  18. Indian J Ophthalmol. 2012 Sep-Oct;60(5):428-31 - PubMed
  19. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29;351(1336):225-31; discussion 231-2 - PubMed
  20. J Vasc Surg. 2009 Dec;50(6):1412-22 - PubMed
  21. J Cell Biochem. 2007 Nov 1;102(4):840-7 - PubMed
  22. PLoS One. 2012;7(10):e48393 - PubMed
  23. PLoS One. 2011;6(10):e26177 - PubMed
  24. Crit Rev Oncol Hematol. 2006 May;58(2):124-45 - PubMed
  25. Front Endocrinol (Lausanne). 2014 Apr 09;5:44 - PubMed
  26. Invest Ophthalmol Vis Sci. 2007 May;48(5):2350-5 - PubMed
  27. J Dent Res. 1965 May-Jun;44:487-92 - PubMed
  28. J Clin Invest. 2003 Jun;111(12 ):1835-42 - PubMed
  29. Exp Diabetes Res. 2012;2012:274363 - PubMed
  30. Circ Cardiovasc Genet. 2010 Jun;3(3):300-6 - PubMed
  31. EMBO J. 2001 Nov 1;20(21):5919-28 - PubMed
  32. World J Gastroenterol. 2007 May 28;13(20):2862-6 - PubMed
  33. Endocrinology. 2015 Apr;156(4):1453-63 - PubMed
  34. Nat Med. 2005 Apr;11(4):400-8 - PubMed
  35. Diabetologia. 2010 May;53(5):966-70 - PubMed
  36. Endocrine. 2012 Dec;42(3):496-505 - PubMed
  37. J Cell Biol. 2003 Jun 23;161(6):1163-77 - PubMed
  38. Placenta. 2011 Mar;32 Suppl 2:S159-64 - PubMed
  39. J Clin Endocrinol Metab. 2013 Sep;98 (9):E1438-47 - PubMed
  40. World J Diabetes. 2015 Apr 15;6(3):489-99 - PubMed
  41. Curr Pharm Des. 2007;13(7):671-86 - PubMed
  42. Clin Sci (Lond). 2012 Mar;122(6):253-70 - PubMed
  43. Diabetologia. 2015 Oct;58(10):2392-402 - PubMed
  44. Cell Metab. 2013 Oct 1;18(4):478-89 - PubMed
  45. Med Res Rev. 2003 Mar;23(2):117-45 - PubMed
  46. Endocr Rev. 2010 Jun;31(3):343-63 - PubMed
  47. Diabetologia. 2009 Sep;52(9):1732-44 - PubMed
  48. J Diabetes Complications. 2015 May-Jun;29(4):568-71 - PubMed
  49. Arch Surg. 1968 Jan;96(1):53-5 - PubMed
  50. Diabetes. 2004 Apr;53(4):963-70 - PubMed
  51. Placenta. 2000 Mar-Apr;21 Suppl A:S16-24 - PubMed
  52. Int J Vasc Med. 2012;2012:918267 - PubMed
  53. J Thorac Cardiovasc Surg. 2007 Dec;134(6):1453-60; discussion 1460 - PubMed
  54. Proc Natl Acad Sci U S A. 1967 Feb;57(2):473-80 - PubMed
  55. Front Physiol. 2016 Mar 15;7:74 - PubMed
  56. Placenta. 2014 Mar;35(3):207-15 - PubMed
  57. Diabetologia. 2010 Jan;53(1):209-11 - PubMed
  58. Mol Cell Biol. 1985 Aug;5(8):2090-103 - PubMed
  59. Nat Med. 2000 Apr;6(4):389-95 - PubMed
  60. Nat Rev Mol Cell Biol. 2009 Mar;10(3):165-77 - PubMed
  61. Diabetes. 2010 Dec;59(12):3008-16 - PubMed
  62. Clin Sci (Lond). 2013 Mar;124(6):351-70 - PubMed
  63. J Biol Chem. 2003 Aug 22;278(34):31964-71 - PubMed
  64. Acta Ophthalmol. 2013 Sep;91(6):e470-3 - PubMed
  65. PLoS One. 2016 Apr 07;11(4):e0153280 - PubMed
  66. Oncotarget. 2014 May 15;5(9):2723-35 - PubMed
  67. Burns. 2014 Dec;40(8):1433-46 - PubMed
  68. Diabetes. 2011 Jun;60(6):1677-87 - PubMed
  69. Am J Physiol Heart Circ Physiol. 2002 Nov;283(5):H1761-8 - PubMed
  70. Ann N Y Acad Sci. 2014 Apr;1311:138-50 - PubMed
  71. Am J Hypertens. 2003 Mar;16(3):223-8 - PubMed
  72. Theor Biol Med Model. 2015 Jul 02;12:13 - PubMed
  73. Stem Cells Int. 2016;2016:1803989 - PubMed
  74. Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5552-8 - PubMed
  75. Circulation. 2002 Jan 22;105(3):373-9 - PubMed
  76. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3225-30 - PubMed
  77. Microvasc Res. 1999 May;57(3):329-39 - PubMed
  78. Am J Med. 1991 Feb 21;90(2A):62S-65S - PubMed
  79. Lancet. 1999 May 22;353(9166):1789-92 - PubMed
  80. Cell Mol Life Sci. 2013 May;70(10):1763-78 - PubMed
  81. PLoS One. 2012;7(12):e50953 - PubMed
  82. Nature. 2011 May 19;473(7347):298-307 - PubMed
  83. J Clin Invest. 1983 Apr;71(4):974-9 - PubMed
  84. BMJ. 2005 Jun 4;330(7503):1304-5 - PubMed
  85. News Physiol Sci. 1999 Jun;14:121-125 - PubMed
  86. Biochem Biophys Res Commun. 2012 Apr 13;420(3):498-504 - PubMed
  87. Eur J Cancer. 2010 Sep;46(13):2369-80 - PubMed
  88. Diabetes. 2000 Jun;49(6):999-1005 - PubMed
  89. J Biochem. 2013 Jan;153(1):13-9 - PubMed
  90. Curr Diab Rep. 2016 Dec;16(12 ):122 - PubMed
  91. Br J Ophthalmol. 2009 Aug;93(8):1109-15 - PubMed
  92. Diabet Med. 2000 Sep;17(9):650-6 - PubMed
  93. Growth Factors. 2011 Dec;29(6):278-89 - PubMed
  94. Exp Cell Res. 2013 May 15;319(9):1271-80 - PubMed
  95. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4492-504 - PubMed
  96. Front Physiol. 2016 Mar 31;7:119 - PubMed
  97. Am J Kidney Dis. 2004 Apr;43(4):636-50 - PubMed
  98. World J Gastroenterol. 2005 Oct 14;11(38):5978-83 - PubMed
  99. Br J Ophthalmol. 1983 Feb;67(2):80-8 - PubMed
  100. J Cell Physiol. 2011 Nov;226(11):2916-24 - PubMed
  101. Genes Dev. 2004 May 1;18(9):1060-71 - PubMed
  102. Invest Ophthalmol Vis Sci. 1993 Nov;34(12):3402-7 - PubMed
  103. Diabetes Care. 2010 Jul;33(7):1674-85 - PubMed
  104. Pflugers Arch. 2004 Jul;448(4):383-94 - PubMed
  105. Arch Dermatol Res. 2009 Feb;301(2):159-66 - PubMed
  106. Eur J Cell Biol. 2003 Apr;82(4):163-73 - PubMed

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