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Siddiqui JA, Partridge NC. CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone. Front Endocrinol (Lausanne). 2017;8:49doi: 10.3389/fendo.2017.00049.
Siddiqui, J. A., & Partridge, N. C. (2017). CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone. Frontiers in endocrinology, 849. https://doi.org/10.3389/fendo.2017.00049
Siddiqui, Jawed Akhtar, and Partridge, Nicola C. "CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone." Frontiers in endocrinology vol. 8 (2017): 49. doi: https://doi.org/10.3389/fendo.2017.00049
Siddiqui JA, Partridge NC. CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone. Front Endocrinol (Lausanne). 2017 Mar 29;8:49. doi: 10.3389/fendo.2017.00049. eCollection 2017. PMID: 28424660; PMCID: PMC5372820.
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Front Endocrinol (Lausanne). 2017 Mar 29;8:49. doi: 10.3389/fendo.2017.00049. eCollection 2017.

CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone.

Frontiers in endocrinology

Jawed Akhtar Siddiqui, Nicola C Partridge

Affiliations

  1. Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA.

PMID: 28424660 PMCID: PMC5372820 DOI: 10.3389/fendo.2017.00049

Abstract

Chemokines are small molecules that play a crucial role as chemoattractants for several cell types, and their components are associated with host immune responses and repair mechanisms. Chemokines selectively recruit monocytes, neutrophils, and lymphocytes and induce chemotaxis through the activation of G protein-coupled receptors. Two well-described chemokine families (CXC and CC) are known to regulate the localization and trafficking of immune cells in cases of injury, infection, and tumors. Monocyte chemoattractant protein 1 (MCP-1/CCL2) is one of the important chemokines from the CC family that controls migration and infiltration of monocytes/macrophages during inflammation. CCL2 is profoundly expressed in osteoporotic bone and prostate cancer-induced bone resorption. CCL2 also regulates physiological bone remodeling in response to hormonal and mechanical stimuli. Parathyroid hormone (PTH) has multifaceted effects on bone, depending on the mode of administration. Intermittent PTH increases bone

Keywords: chemokines; monocyte chemoattractant protein 1; osteoblast; osteoclast; parathyroid hormone and bone remodeling

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