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Briet C, Bourdenet G, Rogner UC, et al. The Spontaneous Autoimmune Neuromyopathy in ICOSL. Front Immunol. 2017;8:287doi: 10.3389/fimmu.2017.00287.
Briet, C., Bourdenet, G., Rogner, U. C., Becourt, C., Tardivel, I., Drouot, L., Arnoult, C., do Rego, J. C., Prevot, N., Massaad, C., Boyer, O., & Boitard, C. (2017). The Spontaneous Autoimmune Neuromyopathy in ICOSL. Frontiers in immunology, 8287. https://doi.org/10.3389/fimmu.2017.00287
Briet, Claire, et al. "The Spontaneous Autoimmune Neuromyopathy in ICOSL." Frontiers in immunology vol. 8 (2017): 287. doi: https://doi.org/10.3389/fimmu.2017.00287
Briet C, Bourdenet G, Rogner UC, Becourt C, Tardivel I, Drouot L, Arnoult C, do Rego JC, Prevot N, Massaad C, Boyer O, Boitard C. The Spontaneous Autoimmune Neuromyopathy in ICOSL. Front Immunol. 2017 Mar 31;8:287. doi: 10.3389/fimmu.2017.00287. eCollection 2017. PMID: 28424681; PMCID: PMC5371727.
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Front Immunol. 2017 Mar 31;8:287. doi: 10.3389/fimmu.2017.00287. eCollection 2017.

The Spontaneous Autoimmune Neuromyopathy in ICOSL.

Frontiers in immunology

Claire Briet, Gwladys Bourdenet, Ute C Rogner, Chantal Becourt, Isabelle Tardivel, Laurent Drouot, Christophe Arnoult, Jean-Claude do Rego, Nicolas Prevot, Charbel Massaad, Olivier Boyer, Christian Boitard

Affiliations

  1. INSERM U1016, Cochin Institute, Paris Descartes University, Sorbonne Paris Cité, Paris, France.
  2. Normandie Université, UNIROUEN, INSERM, U1234, Rouen University Hospital, Department of Immunology, Rouen, France.
  3. INSERM U1016, Cochin Institute, Paris, France.
  4. Normandie Université, UNIROUEN, CNRS, UMR 6270, Rouen, France.
  5. Normandie Université, UNIROUEN, SCAC, INSERM, U1234, Rouen, France.
  6. Developmental Immunology, Department of Paediatrics, and the Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  7. INSERM UMR S1124, Paris Descartes University, Paris, France.

PMID: 28424681 PMCID: PMC5371727 DOI: 10.3389/fimmu.2017.00287

Abstract

Abrogation of ICOS/ICOS ligand (ICOSL) costimulation prevents the onset of diabetes in the non-obese diabetic (NOD) mouse but, remarkably, yields to the development of a spontaneous autoimmune neuromyopathy. At the pathological level, ICOSL

Keywords: ICOS; ICOSL; autoimmunity; costimulation; myopathy; neuropathy; type 1 diabetes

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