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Godlewska U, Brzoza P, Sroka A, et al. Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease. Front Immunol. 2017;8:353doi: 10.3389/fimmu.2017.00353.
Godlewska, U., Brzoza, P., Sroka, A., Majewski, P., Jentsch, H., Eckert, M., Eick, S., Potempa, J., Zabel, B. A., & Cichy, J. (2017). Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease. Frontiers in immunology, 8353. https://doi.org/10.3389/fimmu.2017.00353
Godlewska, Urszula, et al. "Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease." Frontiers in immunology vol. 8 (2017): 353. doi: https://doi.org/10.3389/fimmu.2017.00353
Godlewska U, Brzoza P, Sroka A, Majewski P, Jentsch H, Eckert M, Eick S, Potempa J, Zabel BA, Cichy J. Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease. Front Immunol. 2017 Mar 29;8:353. doi: 10.3389/fimmu.2017.00353. eCollection 2017. PMID: 28424689; PMCID: PMC5372799.
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Front Immunol. 2017 Mar 29;8:353. doi: 10.3389/fimmu.2017.00353. eCollection 2017.

Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease.

Frontiers in immunology

Urszula Godlewska, Piotr Brzoza, Aneta Sroka, Pawel Majewski, Holger Jentsch, Martin Eckert, Sigrun Eick, Jan Potempa, Brian A Zabel, Joanna Cichy

Affiliations

  1. Faculty of Biochemistry, Biophysics and Biotechnology, Department of Immunology, Jagiellonian University, Kraków, Poland.
  2. Faculty of Biochemistry, Biophysics and Biotechnology, Department of Microbiology, Jagiellonian University, Kraków, Poland.
  3. Centre for Periodontology, Department of Cariology, Endodontology and Periodontology, University Hospital of Leipzig, Leipzig, Germany.
  4. Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
  5. Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.
  6. Palo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, USA.

PMID: 28424689 PMCID: PMC5372799 DOI: 10.3389/fimmu.2017.00353

Abstract

Periodontal inflammation is one of the most common chronic inflammatory conditions in humans. Despite recent advances in identifying and characterizing oral microbiota dysbiosis in the pathogenesis of gum disease, just how host factors maintain a healthy homeostatic oral microbial community or prevent the development of a pathogenic oral microbiota remains poorly understood. An important determinant of microbiota fate is local antimicrobial proteins. Here, we report that chemoattractant protein chemerin, which we recently identified as a potent endogenous antimicrobial agent in body barriers such as the skin, is present in the oral cavity under homeostatic and inflammatory conditions. Chemerin and a chemerin-derived antimicrobial peptide are bactericidal against select bacteria strategically positioned in dental biofilm. Gingival crevicular samples from patients with gingivitis but not periodontitis contain abundant bioactive chemerin capable of inducing CMKLR1-dependent leukocyte migration. Gingipains secreted by the periodontopathogen

Keywords: antimicrobial peptides; chemerin; chemoattractant; inflammation mediators; microbiota; oral cavity

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