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Cicone F, Viertl D, Quintela Pousa AM, et al. Cardiac Radionuclide Imaging in Rodents: A Review of Methods, Results, and Factors at Play. Front Med (Lausanne). 2017;4:35doi: 10.3389/fmed.2017.00035.
Cicone, F., Viertl, D., Quintela Pousa, A. M., Denoël, T., Gnesin, S., Scopinaro, F., Vozenin, M. C., & Prior, J. O. (2017). Cardiac Radionuclide Imaging in Rodents: A Review of Methods, Results, and Factors at Play. Frontiers in medicine, 435. https://doi.org/10.3389/fmed.2017.00035
Cicone, Francesco, et al. "Cardiac Radionuclide Imaging in Rodents: A Review of Methods, Results, and Factors at Play." Frontiers in medicine vol. 4 (2017): 35. doi: https://doi.org/10.3389/fmed.2017.00035
Cicone F, Viertl D, Quintela Pousa AM, Denoël T, Gnesin S, Scopinaro F, Vozenin MC, Prior JO. Cardiac Radionuclide Imaging in Rodents: A Review of Methods, Results, and Factors at Play. Front Med (Lausanne). 2017 Mar 29;4:35. doi: 10.3389/fmed.2017.00035. eCollection 2017. PMID: 28424774; PMCID: PMC5372793.
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Front Med (Lausanne). 2017 Mar 29;4:35. doi: 10.3389/fmed.2017.00035. eCollection 2017.

Cardiac Radionuclide Imaging in Rodents: A Review of Methods, Results, and Factors at Play.

Frontiers in medicine

Francesco Cicone, David Viertl, Ana Maria Quintela Pousa, Thibaut Denoël, Silvano Gnesin, Francesco Scopinaro, Marie-Catherine Vozenin, John O Prior

Affiliations

  1. Department of Nuclear Medicine and Molecular Imaging, University Hospital of Lausanne, Lausanne, Switzerland.
  2. Nuclear Medicine, Department of Surgical and Medical Sciences and Translational Medicine, "Sapienza" University of Rome, Rome, Italy.
  3. Laboratory of Radiation Oncology, Service of Radiation-Oncology, Department of Oncology, University Hospital of Lausanne, Lausanne, Switzerland.
  4. Institute of Radiation Physics, University Hospital of Lausanne, Lausanne, Switzerland.

PMID: 28424774 PMCID: PMC5372793 DOI: 10.3389/fmed.2017.00035

Abstract

The interest around small-animal cardiac radionuclide imaging is growing as rodent models can be manipulated to allow the simulation of human diseases. In addition to new radiopharmaceuticals testing, often researchers apply well-established probes to animal models, to follow the evolution of the target disease. This reverse translation of standard radiopharmaceuticals to rodent models is complicated by technical shortcomings and by obvious differences between human and rodent cardiac physiology. In addition, radionuclide studies involving small animals are affected by several extrinsic variables, such as the choice of anesthetic. In this paper, we review the major cardiac features that can be studied with classical single-photon and positron-emitting radiopharmaceuticals, namely, cardiac function, perfusion and metabolism, as well as the results and pitfalls of small-animal radionuclide imaging techniques. In addition, we provide a concise guide to the understanding of the most frequently used anesthetics such as ketamine/xylazine, isoflurane, and pentobarbital. We address in particular their mechanisms of action and the potential effects on radionuclide imaging. Indeed, cardiac function, perfusion, and metabolism can all be significantly affected by varying anesthetics and animal handling conditions.

Keywords: 18F-FDG PET; anesthesia; cardiac imaging; micro-PET; micro-SPECT; myocardial scintigraphy; rodents; small-animal imaging

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