Display options
Cite
Wang PP, Wang GX, Ge WT, et al. Nasal nitric oxide in allergic rhinitis in children and its relationship to severity and treatment. Allergy Asthma Clin Immunol. 2017;13:20doi: 10.1186/s13223-017-0191-z.
Wang, P. P., Wang, G. X., Ge, W. T., Tang, L. X., Zhang, J., & Ni, X. (2017). Nasal nitric oxide in allergic rhinitis in children and its relationship to severity and treatment. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 1320. https://doi.org/10.1186/s13223-017-0191-z
Wang, Peng-Peng, et al. "Nasal nitric oxide in allergic rhinitis in children and its relationship to severity and treatment." Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology vol. 13 (2017): 20. doi: https://doi.org/10.1186/s13223-017-0191-z
Wang PP, Wang GX, Ge WT, Tang LX, Zhang J, Ni X. Nasal nitric oxide in allergic rhinitis in children and its relationship to severity and treatment. Allergy Asthma Clin Immunol. 2017 Apr 04;13:20. doi: 10.1186/s13223-017-0191-z. eCollection 2017. PMID: 28396691; PMCID: PMC5381136.
Copy Download .nbib Format: NLM
Share it on

Allergy Asthma Clin Immunol. 2017 Apr 04;13:20. doi: 10.1186/s13223-017-0191-z. eCollection 2017.

Nasal nitric oxide in allergic rhinitis in children and its relationship to severity and treatment.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

Peng-Peng Wang, Gui-Xiang Wang, Wen-Tong Ge, Li-Xing Tang, Jie Zhang, Xin Ni

Affiliations

  1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, 56 Nan Li Shi Road Xi Cheng District, Beijing, 100045 People's Republic of China.

PMID: 28396691 PMCID: PMC5381136 DOI: 10.1186/s13223-017-0191-z

Abstract

BACKGROUND: Nasal nitrous oxide (nNO) is increased in allergic rhinitis (AR), but not in asthma, and is a non-invasive marker for inflammation in the nasal passages.

METHODS: Levels of nNO were measured and compared in healthy children and children with mild and moderate-to-severe AR. Levels of nNO before and after treatment with steroids and/or antihistamine were then compared in the 2 AR groups. Their relationship to quality of life and nasal symptom and reactivity to outdoor and outdoor allergens were examined.

RESULTS: nNO levels were higher in mild AR than in healthy children and higher in moderate-to-severe AR than in mild AR. One month steroid and/or antihistamine treatment lowered nNO levels to control levels in mild AR and approximately halfway to control levels in moderate-to-severe AR. nNO levels had a weak correlation to quality of life questions and a fair correlation to nasal symptom scores before treatment. This correlation was weakened or lost after treatment, and no correlation was seen between nNO levels and responses to indoor or outdoor allergens.

CONCLUSION: nNO levels in children with AR may be useful for assessing the response to treatment. Their relationship to quality of life, nasal symptoms, and sensitivity to specific allergens needs further study.

Keywords: Allergic rhinitis; Nasal symptoms; Quality of life; nNO

References

  1. Clin Exp Otorhinolaryngol. 2012 Dec;5(4):228-33 - PubMed
  2. Laryngoscope. 2014 Jun;124(6):E213-8 - PubMed
  3. Biomarkers. 2014 Sep;19(6):481-7 - PubMed
  4. J Clin Invest. 1998 Sep 15;102(6):1200-7 - PubMed
  5. J Asthma. 2011 Dec;48(10):1001-6 - PubMed
  6. Am J Rhinol Allergy. 2011 Nov-Dec;25(6):383-7 - PubMed
  7. J Asthma. 2010 Dec;47(10):1142-7 - PubMed
  8. Ann Allergy Asthma Immunol. 2008 Oct;101(4):358-62 - PubMed
  9. Allergy. 2008 Apr;63 Suppl 86:8-160 - PubMed
  10. Am J Rhinol Allergy. 2014 Jan-Feb;28(1):e11-6 - PubMed
  11. Am J Rhinol Allergy. 2012 Mar-Apr;26(2):e50-4 - PubMed
  12. Am J Respir Crit Care Med. 2005 Apr 15;171(8):912-30 - PubMed
  13. Iran J Allergy Asthma Immunol. 2011 Dec;10(4):251-60 - PubMed
  14. Eur Respir J. 2002 Jul;20(1):223-37 - PubMed
  15. Pediatr Pulmonol. 2015 Jan;50(1):85-99 - PubMed
  16. Int J Pediatr Otorhinolaryngol. 2015 Dec;79(12):2308-11 - PubMed

Publication Types