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Yagi M, Oxley D, Dendooven P, et al. SU-E-T-294: Maximizing the Availability of Positron Emitting Nuclei for Proton Therapy Verification Using Different Beam Irradiation Sequences. Med Phys. 2012;39(6):3771doi: 10.1118/1.4735364.
Yagi, M., Oxley, D., Dendooven, P., Brandenburg, S., Koizumi, M., & Teshima, T. (2012). SU-E-T-294: Maximizing the Availability of Positron Emitting Nuclei for Proton Therapy Verification Using Different Beam Irradiation Sequences. Medical physics, 39(6), 3771. https://doi.org/10.1118/1.4735364
Yagi, M, et al. "SU-E-T-294: Maximizing the Availability of Positron Emitting Nuclei for Proton Therapy Verification Using Different Beam Irradiation Sequences." Medical physics vol. 39,6 (2012): 3771. doi: https://doi.org/10.1118/1.4735364
Yagi M, Oxley D, Dendooven P, Brandenburg S, Koizumi M, Teshima T. SU-E-T-294: Maximizing the Availability of Positron Emitting Nuclei for Proton Therapy Verification Using Different Beam Irradiation Sequences. Med Phys. 2012 Jun;39(6):3771. doi: 10.1118/1.4735364. PMID: 28517256.
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Med Phys. 2012 Jun;39(6):3771. doi: 10.1118/1.4735364.

SU-E-T-294: Maximizing the Availability of Positron Emitting Nuclei for Proton Therapy Verification Using Different Beam Irradiation Sequences.

Medical physics

M Yagi, D Oxley, P Dendooven, S Brandenburg, M Koizumi, T Teshima

Affiliations

  1. Kernfysisch Versneller Instituut, Groningen, Groningen.
  2. Osaka University Hospital, Suita, Osaka.
  3. Osaka University, Suita, Osaka.

PMID: 28517256 DOI: 10.1118/1.4735364

Abstract

PURPOSE: To demonstrate that the amount of nuclei available for post- irradiation proton treatment verification using positron emission tomography (PET) can be enhanced by reversing the beam delivery sequence in proton scanning beam irradiations.

METHODS: A time-dependent analytical model is used to calculate the distributions of positron emitting nuclei for three different irradiation sequences: a scattered beam and a scanning beam in both the conventional sequence, distal edge first, and reverse sequence, distal edge last. The simulated geometry emulates reference dosimetry measurements conducted at the Paul Scherrer Institute (PSI). The reference measurements irradiate a 10 ×10 cm

RESULTS: The ratio of the amount of positron emitters from the distal last beam sequence to that from the distal first sequence was 2.22 in the last centimeter of the SOBP. The comparison between distal last and a scattered beam gave a ratio of about 1.7 in the same region. In the distal last irradiation, more isotopes decay within a 120 second window, than in a 240 second window using a distal first irradiation. The statistical fluctuation on a range extrapolation was also smallest in the distal last beam sequence.

CONCLUSIONS: We demonstrated the effect of the irradiation beam sequence on the isotope production relevant for the verification of proton spot scanning therapy with PET. The largest amount of isotopes is available by irradiating the distal edge last. This new beam sequence reduces the PETmeasurement time while still offering higher counts and accuracy compared with both the conventional beam sequence and the scattering method. This project was supported by JSPS Core-to-Core Program.

© 2012 American Association of Physicists in Medicine.

Keywords: Biomedical modeling; Dosimetry; Drug delivery; Isotopes; Positron beams; Positron emission tomography; Positrons; Proton therapy; Protons; Sequence analysis

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