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Badura-Brack AS, Heinrichs-Graham E, McDermott TJ, et al. Resting-State Neurophysiological Abnormalities in Posttraumatic Stress Disorder: A Magnetoencephalography Study. Front Hum Neurosci. 2017;11:205doi: 10.3389/fnhum.2017.00205.
Badura-Brack, A. S., Heinrichs-Graham, E., McDermott, T. J., Becker, K. M., Ryan, T. J., Khanna, M. M., & Wilson, T. W. (2017). Resting-State Neurophysiological Abnormalities in Posttraumatic Stress Disorder: A Magnetoencephalography Study. Frontiers in human neuroscience, 11205. https://doi.org/10.3389/fnhum.2017.00205
Badura-Brack, Amy S, et al. "Resting-State Neurophysiological Abnormalities in Posttraumatic Stress Disorder: A Magnetoencephalography Study." Frontiers in human neuroscience vol. 11 (2017): 205. doi: https://doi.org/10.3389/fnhum.2017.00205
Badura-Brack AS, Heinrichs-Graham E, McDermott TJ, Becker KM, Ryan TJ, Khanna MM, Wilson TW. Resting-State Neurophysiological Abnormalities in Posttraumatic Stress Disorder: A Magnetoencephalography Study. Front Hum Neurosci. 2017 Apr 25;11:205. doi: 10.3389/fnhum.2017.00205. eCollection 2017. PMID: 28487642; PMCID: PMC5403896.
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Front Hum Neurosci. 2017 Apr 25;11:205. doi: 10.3389/fnhum.2017.00205. eCollection 2017.

Resting-State Neurophysiological Abnormalities in Posttraumatic Stress Disorder: A Magnetoencephalography Study.

Frontiers in human neuroscience

Amy S Badura-Brack, Elizabeth Heinrichs-Graham, Timothy J McDermott, Katherine M Becker, Tara J Ryan, Maya M Khanna, Tony W Wilson

Affiliations

  1. Department of Psychology, Creighton UniversityOmaha, NE, USA.
  2. Center for Magnetoencephalography (MEG), University of Nebraska Medical Center (UNMC)Omaha, NE, USA.
  3. Department of Neurological Sciences, University of Nebraska Medical Center (UNMC)Omaha, NE, USA.
  4. Department of Psychology, Colorado State UniversityFort Collins, CO, USA.
  5. Department of Psychology, Simon Fraser UniversityBurnaby, BC, Canada.

PMID: 28487642 PMCID: PMC5403896 DOI: 10.3389/fnhum.2017.00205

Abstract

Posttraumatic stress disorder (PTSD) is a debilitating psychiatric condition that is common in veterans returning from combat operations. While the symptoms of PTSD have been extensively characterized, the neural mechanisms that underlie PTSD are only vaguely understood. In this study, we examined the neurophysiology of PTSD using magnetoencephalography (MEG) in a sample of veterans with and without PTSD. Our primary hypothesis was that veterans with PTSD would exhibit aberrant activity across multiple brain networks, especially those involving medial temporal and frontal regions. To this end, we examined a total of 51 USA combat veterans with a battery of clinical interviews and tests. Thirty-one of the combat veterans met diagnostic criteria for PTSD and the remaining 20 did not have PTSD. All participants then underwent high-density MEG during an eyes-closed resting-state task, and the resulting data were analyzed using a Bayesian image reconstruction method. Our results indicated that veterans with PTSD had significantly stronger neural activity in prefrontal, sensorimotor and temporal areas compared to those without PTSD. Veterans with PTSD also exhibited significantly stronger activity in the bilateral amygdalae, parahippocampal and hippocampal regions. Conversely, healthy veterans had stronger neural activity in the bilateral occipital cortices relative to veterans with PTSD. In conclusion, these data suggest that veterans with PTSD exhibit aberrant neural activation in multiple cortical areas, as well as medial temporal structures implicated in affective processing.

Keywords: MEG; PTSD; magnetoencephalography (MEG); posttraumatic stress disorder; resting-state

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