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Paudel A, Hamamoto H, Panthee S, et al. A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in . Front Microbiol. 2017;8:712doi: 10.3389/fmicb.2017.00712.
Paudel, A., Hamamoto, H., Panthee, S., Kaneko, K., Matsunaga, S., Kanai, M., Suzuki, Y., & Sekimizu, K. (2017). A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in . Frontiers in microbiology, 8712. https://doi.org/10.3389/fmicb.2017.00712
Paudel, Atmika, et al. "A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in ." Frontiers in microbiology vol. 8 (2017): 712. doi: https://doi.org/10.3389/fmicb.2017.00712
Paudel A, Hamamoto H, Panthee S, Kaneko K, Matsunaga S, Kanai M, Suzuki Y, Sekimizu K. A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in . Front Microbiol. 2017 Apr 25;8:712. doi: 10.3389/fmicb.2017.00712. eCollection 2017. PMID: 28487682; PMCID: PMC5403886.
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Front Microbiol. 2017 Apr 25;8:712. doi: 10.3389/fmicb.2017.00712. eCollection 2017.

A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in .

Frontiers in microbiology

Atmika Paudel, Hiroshi Hamamoto, Suresh Panthee, Keiichi Kaneko, Shigeki Matsunaga, Motomu Kanai, Yutaka Suzuki, Kazuhisa Sekimizu

Affiliations

  1. Institute of Medical Mycology, Teikyo UniversityHachioji, Tokyo, Japan.
  2. Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of TokyoTokyo, Japan.
  3. Department of Medical Genome Science, Graduate School of Frontier Sciences, The University of TokyoKashiwa, Japan.
  4. Genome Pharmaceuticals Institute Co., Ltd.Bunkyo, Tokyo, Japan.

PMID: 28487682 PMCID: PMC5403886 DOI: 10.3389/fmicb.2017.00712

Abstract

Synthetic compounds are a vital source of antimicrobial agents. To uncover therapeutically effective antimicrobial agents from a chemical library, we screened over 100,000 synthetic compounds for

Keywords: RNA polymerase; anti-staphylococcal; antimicrobial agent; chemical library; sigma factor; silkworm infection model; therapeutic activity

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