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Papakonstantinou VD, Lagopati N, Tsilibary EC, et al. A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?. Bioinorg Chem Appl. 2017;2017:6947034doi: 10.1155/2017/6947034.
Papakonstantinou, V. D., Lagopati, N., Tsilibary, E. C., Demopoulos, C. A., & Philippopoulos, A. I. (2017). A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?. Bioinorganic chemistry and applications, 20176947034. https://doi.org/10.1155/2017/6947034
Papakonstantinou, Vasiliki D, et al. "A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?." Bioinorganic chemistry and applications vol. 2017 (2017): 6947034. doi: https://doi.org/10.1155/2017/6947034
Papakonstantinou VD, Lagopati N, Tsilibary EC, Demopoulos CA, Philippopoulos AI. A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?. Bioinorg Chem Appl. 2017;2017:6947034. doi: 10.1155/2017/6947034. Epub 2017 Mar 28. PMID: 28458618; PMCID: PMC5387815.
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Bioinorg Chem Appl. 2017;2017:6947034. doi: 10.1155/2017/6947034. Epub 2017 Mar 28.

A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?.

Bioinorganic chemistry and applications

Vasiliki D Papakonstantinou, Nefeli Lagopati, Effie C Tsilibary, Constantinos A Demopoulos, Athanassios I Philippopoulos

Affiliations

  1. Laboratory of Biochemistry, Faculty of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece.
  2. Institute of Biosciences & Applications, NCSR Demokritos, 15310 Agia Paraskevi, Greece.
  3. Laboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.

PMID: 28458618 PMCID: PMC5387815 DOI: 10.1155/2017/6947034

Abstract

In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminary

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