Display options
Cite
Goel PK, Ashfaq F, Khanna R, et al. The Association Between Small Dense Low Density Lipoprotein and Coronary Artery Disease in North Indian Patients. Indian J Clin Biochem. 2016;32(2):186-192doi: 10.1007/s12291-016-0592-7.
Goel, P. K., Ashfaq, F., Khanna, R., Ramesh, V., & Pandey, C. M. (2017). The Association Between Small Dense Low Density Lipoprotein and Coronary Artery Disease in North Indian Patients. Indian journal of clinical biochemistry : IJCB, 32(2), 186-192. https://doi.org/10.1007/s12291-016-0592-7
Goel, Pravin K, et al. "The Association Between Small Dense Low Density Lipoprotein and Coronary Artery Disease in North Indian Patients." Indian journal of clinical biochemistry : IJCB vol. 32,2 (2017): 186-192. doi: https://doi.org/10.1007/s12291-016-0592-7
Goel PK, Ashfaq F, Khanna R, Ramesh V, Pandey CM. The Association Between Small Dense Low Density Lipoprotein and Coronary Artery Disease in North Indian Patients. Indian J Clin Biochem. 2017 Jun;32(2):186-192. doi: 10.1007/s12291-016-0592-7. Epub 2016 Jul 04. PMID: 28428693; PMCID: PMC5382077.
Copy Download .nbib Format: NLM
Share it on

Indian J Clin Biochem. 2017 Jun;32(2):186-192. doi: 10.1007/s12291-016-0592-7. Epub 2016 Jul 04.

The Association Between Small Dense Low Density Lipoprotein and Coronary Artery Disease in North Indian Patients.

Indian journal of clinical biochemistry : IJCB

Pravin K Goel, Fauzia Ashfaq, Roopali Khanna, V Ramesh, Chandra Mohan Pandey

Affiliations

  1. Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
  2. Department of Biochemistry, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
  3. Department of Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

PMID: 28428693 PMCID: PMC5382077 DOI: 10.1007/s12291-016-0592-7

Abstract

Pathogenesis of coronary artery disease (CAD) is multi-factorial and several conventional risk factors have been ascribed; LDL-C being one of the important risk factor. However Indian population studies with established CAD often show LDL levels within normal range in patients with proven CAD. We hypothesized that Small dense low density lipoprotein (sdLDL) being more atherogenic might correlate more strongly to the occurrence and severity of CAD. The aim of the study was to evaluate the association between serum small dense LDL level and angiographically documented coronary artery disease. This is a cross sectional case control study in which sdLDL were measured in 126 patients with CAD and in 64 patients without CAD. Total cholesterol, HDL Cholesterol, LDL cholesterol and triglycerides were measured by standard methods along with other traditional risk factors. Direct quantitative measurement of sdLDL was done by enzymatic analysis. Mean sdLDL level was higher in patients with coronary stenosis than patients without coronary stenosis (16.3 ± 6.8 vs. 10.1 ± 5.7 mg/dL respectively, (

Keywords: Coronary artery disease; Fasting lipid profile; LDL sub fractions; Lipid metabolism; sdLDL

References

  1. Atherosclerosis. 2002 Jan;160(1):249-56 - PubMed
  2. J Assoc Physicians India. 2005 Feb;53:95-100 - PubMed
  3. Lipids Health Dis. 2011 Jan 25;10 :21 - PubMed
  4. Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):196-201 - PubMed
  5. J Am Coll Cardiol. 2013 Aug 20;62(8):732-9 - PubMed
  6. J Am Coll Cardiol. 2008 Aug 19;52(8):636-43 - PubMed
  7. N Engl J Med. 2009 Mar 5;360(10):961-72 - PubMed
  8. Horm Metab Res. 1995 Jul;27(7):326-31 - PubMed
  9. J Clin Endocrinol Metab. 2003 Oct;88(10):4525-32 - PubMed
  10. Atherosclerosis. 1994 Apr;106(2):241-53 - PubMed
  11. Thromb Haemost. 1997 Dec;78(6):1495-9 - PubMed
  12. Tex Heart Inst J. 2010;37(4):421-8 - PubMed
  13. Circulation. 1997 Jan 7;95(1):69-75 - PubMed
  14. J Am Coll Cardiol. 2001 Sep;38(3):682-7 - PubMed
  15. Arterioscler Thromb Vasc Biol. 1999 Nov;19(11):2749-55 - PubMed
  16. Circulation. 2004 Jun 29;109(25):3112-21 - PubMed
  17. Arterioscler Thromb Vasc Biol. 2014 May;34(5):1069-77 - PubMed
  18. Indian Heart J. 2003 May-Jun;55(3):234-40 - PubMed
  19. Arq Bras Cardiol. 2008 Jan;90(1):24-30 - PubMed
  20. Curr Opin Lipidol. 1994 Oct;5(5):339-49 - PubMed

Publication Types