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Front Neurosci. 2017 Apr 06;11:182. doi: 10.3389/fnins.2017.00182. eCollection 2017.

High Salt Intake Augments Excitability of PVN Neurons in Rats: Role of the Endoplasmic Reticulum Ca.

Frontiers in neuroscience

Robert A Larson, Andrew D Chapp, Le Gui, Michael J Huber, Zixi Jack Cheng, Zhiying Shan, Qing-Hui Chen

Affiliations

  1. Department of Kinesiology and Integrative Physiology, Michigan Technological UniversityHoughton, MI, USA.
  2. Department of Cardiology, Affiliated Hospital of Nantong UniversityNantong, China.
  3. Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central FloridaOrlando, FL, USA.

PMID: 28428739 PMCID: PMC5382644 DOI: 10.3389/fnins.2017.00182

Abstract

High salt (HS) intake sensitizes central autonomic circuitry leading to sympathoexcitation. However, its underlying mechanisms are not fully understood. We hypothesized that inhibition of PVN endoplasmic reticulum (ER) Ca

Keywords: endoplasmic reticulum; high salt diet; hypertension; paraventricular nucleus; sympathetic nerve activity

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