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Purwin M, Markowska A, Bruzgo I, et al. Peptides with 6-Aminohexanoic Acid: Synthesis and Evaluation as Plasmin Inhibitors. Int J Pept Res Ther. 2016;23(2):235-245doi: 10.1007/s10989-016-9555-3.
Purwin, M., Markowska, A., Bruzgo, I., Rusak, T., Surażyński, A., Jaworowska, U., & Midura-Nowaczek, K. (2017). Peptides with 6-Aminohexanoic Acid: Synthesis and Evaluation as Plasmin Inhibitors. International journal of peptide research and therapeutics, 23(2), 235-245. https://doi.org/10.1007/s10989-016-9555-3
Purwin, Maciej, et al. "Peptides with 6-Aminohexanoic Acid: Synthesis and Evaluation as Plasmin Inhibitors." International journal of peptide research and therapeutics vol. 23,2 (2017): 235-245. doi: https://doi.org/10.1007/s10989-016-9555-3
Purwin M, Markowska A, Bruzgo I, Rusak T, Surażyński A, Jaworowska U, Midura-Nowaczek K. Peptides with 6-Aminohexanoic Acid: Synthesis and Evaluation as Plasmin Inhibitors. Int J Pept Res Ther. 2017;23(2):235-245. doi: 10.1007/s10989-016-9555-3. Epub 2016 Sep 19. PMID: 28491013; PMCID: PMC5401710.
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Int J Pept Res Ther. 2017;23(2):235-245. doi: 10.1007/s10989-016-9555-3. Epub 2016 Sep 19.

Peptides with 6-Aminohexanoic Acid: Synthesis and Evaluation as Plasmin Inhibitors.

International journal of peptide research and therapeutics

Maciej Purwin, Agnieszka Markowska, Irena Bruzgo, Tomasz Rusak, Arkadiusz Surażyński, Urszula Jaworowska, Krystyna Midura-Nowaczek

Affiliations

  1. Department of Organic Chemistry, Medical University of Bialystok, Mickiewicza 2A Str, 15-222 Bia?ystok, Poland.
  2. Department of Physical Chemistry, Medical University of Bialystok, Mickiewicza 2A Str, 15-222 Bia?ystok, Poland.
  3. Department of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2A Str, 15-222 Bia?ystok, Poland.

PMID: 28491013 PMCID: PMC5401710 DOI: 10.1007/s10989-016-9555-3

Abstract

Fifteen new peptide derivatives of ɛ-aminocaproic acid (EACA) containing the known fragment -Ala-Phe-Lys- with an affinity for plasmin were synthesised in the present study. The synthesis was carried out a solid phase. The following compounds were synthesised: H-Phe-Lys-EACA-X, H-d-Ala-Phe-Lys-EACA-X, H-Ala-Phe-Lys-EACA-X, H-d-Ala-Phe-EACA-X and H-Ala-Phe-EACA-X, where X = OH, NH

Keywords: 6-Aminohexanoic acid; Antifibrinolytics; Plasmin inhibitors

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