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Procopiou PA, Ford AJ, Gore PM, et al. Design of Phthalazinone Amide Histamine H. ACS Med Chem Lett. 2017;8(5):577-581doi: 10.1021/acsmedchemlett.7b00112.
Procopiou, P. A., Ford, A. J., Gore, P. M., Looker, B. E., Hodgson, S. T., Holmes, D. S., Vile, S., Clark, K. L., Saunders, K. A., Slack, R. J., Rowedder, J. E., & Watts, C. J. (2017). Design of Phthalazinone Amide Histamine H. ACS medicinal chemistry letters, 8(5), 577-581. https://doi.org/10.1021/acsmedchemlett.7b00112
Procopiou, Panayiotis A, et al. "Design of Phthalazinone Amide Histamine H." ACS medicinal chemistry letters vol. 8,5 (2017): 577-581. doi: https://doi.org/10.1021/acsmedchemlett.7b00112
Procopiou PA, Ford AJ, Gore PM, Looker BE, Hodgson ST, Holmes DS, Vile S, Clark KL, Saunders KA, Slack RJ, Rowedder JE, Watts CJ. Design of Phthalazinone Amide Histamine H. ACS Med Chem Lett. 2017 Apr 21;8(5):577-581. doi: 10.1021/acsmedchemlett.7b00112. eCollection 2017 May 11. PMID: 28523114; PMCID: PMC5430406.
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ACS Med Chem Lett. 2017 Apr 21;8(5):577-581. doi: 10.1021/acsmedchemlett.7b00112. eCollection 2017 May 11.

Design of Phthalazinone Amide Histamine H.

ACS medicinal chemistry letters

Panayiotis A Procopiou, Alison J Ford, Paul M Gore, Brian E Looker, Simon T Hodgson, Duncan S Holmes, Sadie Vile, Kenneth L Clark, Ken A Saunders, Robert J Slack, James E Rowedder, Clarissa J Watts

Affiliations

  1. Medicinal Chemistry, Respiratory Biology, R&D Platform Technology and Science, and Drug Metabolism and Pharmacokinetcs, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom.

PMID: 28523114 PMCID: PMC5430406 DOI: 10.1021/acsmedchemlett.7b00112

Abstract

The synthesis of potent amide-containing phthalazinone H

Keywords: Histamine H1 receptor antagonist; allergic rhinitis; once-daily dosing; phthalazinone; topical application

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