Display options
Share it on

ACS Med Chem Lett. 2017 Apr 25;8(5):582-586. doi: 10.1021/acsmedchemlett.7b00157. eCollection 2017 May 11.

Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP.

ACS medicinal chemistry letters

David A Sandham, Lucy Barker, Lyndon Brown, Zarin Brown, David Budd, Steven J Charlton, Devnandan Chatterjee, Brian Cox, Gerald Dubois, Nicholas Duggan, Edward Hall, Julia Hatto, Janet Maas, Jodie Manini, Rachael Profit, Darren Riddy, Catherine Ritchie, Bindi Sohal, Duncan Shaw, Rowan Stringer, David A Sykes, Matthew Thomas, Katharine L Turner, Simon J Watson, Ryan West, Elisabeth Willard, Gareth Williams, Jennifer Willis

Affiliations

  1. Novartis Institutes for Biomedical Research, Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex RH12 5AB, United Kingdom.

PMID: 28523115 PMCID: PMC5430394 DOI: 10.1021/acsmedchemlett.7b00157

Abstract

Further optimization of an initial DP

Keywords: DP2 receptor antagonist; clinical candidate; severe asthma

References

  1. Pharmacol Res. 2016 Sep;111:208-16 - PubMed
  2. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6288-92 - PubMed
  3. Lancet. 2016 Jul 2;388(10039):31-44 - PubMed
  4. J Exp Med. 2001 Jan 15;193(2):255-61 - PubMed
  5. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5118-22 - PubMed
  6. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5127-33 - PubMed
  7. Lancet Respir Med. 2016 Sep;4(9):699-707 - PubMed
  8. J Pharmacol Exp Ther. 2012 Nov;343(2):520-8 - PubMed
  9. Allergy Asthma Immunol Res. 2013 Nov;5(6):409-14 - PubMed
  10. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7 - PubMed
  11. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5123-6 - PubMed
  12. Clin Pharmacol Drug Dev. 2016 Jul;5(4):306-13 - PubMed
  13. Expert Opin Investig Drugs. 2014 Jan;23(1):55-66 - PubMed
  14. J Allergy Clin Immunol. 2014 Apr;133(4):1184-94 - PubMed
  15. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5111-7 - PubMed
  16. Mol Pharmacol. 2016 May;89(5):593-605 - PubMed
  17. Ann Allergy Asthma Immunol. 2012 Dec;109(6):365-74 - PubMed
  18. Pulm Pharmacol Ther. 2016 Aug;39:54-63 - PubMed
  19. Bioorg Med Chem. 2013 Nov 1;21(21):6582-91 - PubMed

Publication Types