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Shiotsuka J, Steel A, Downar J. The Sedative Effect of Propranolol on Critically Ill Patients: A Case Series. Front Med (Lausanne). 2017;4:44doi: 10.3389/fmed.2017.00044.
Shiotsuka, J., Steel, A., & Downar, J. (2017). The Sedative Effect of Propranolol on Critically Ill Patients: A Case Series. Frontiers in medicine, 444. https://doi.org/10.3389/fmed.2017.00044
Shiotsuka, Junji, et al. "The Sedative Effect of Propranolol on Critically Ill Patients: A Case Series." Frontiers in medicine vol. 4 (2017): 44. doi: https://doi.org/10.3389/fmed.2017.00044
Shiotsuka J, Steel A, Downar J. The Sedative Effect of Propranolol on Critically Ill Patients: A Case Series. Front Med (Lausanne). 2017 May 04;4:44. doi: 10.3389/fmed.2017.00044. eCollection 2017. PMID: 28523268; PMCID: PMC5415564.
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Front Med (Lausanne). 2017 May 04;4:44. doi: 10.3389/fmed.2017.00044. eCollection 2017.

The Sedative Effect of Propranolol on Critically Ill Patients: A Case Series.

Frontiers in medicine

Junji Shiotsuka, Andrew Steel, James Downar

Affiliations

  1. Division of Critical Care, University Health Network, Toronto, ON, Canada.
  2. Department of Anaesthesiology, University Health Network, Toronto, ON, Canada.

PMID: 28523268 PMCID: PMC5415564 DOI: 10.3389/fmed.2017.00044

Abstract

INTRODUCTION: Recent studies have examined the effectiveness of alpha-2 adrenergic agonists for controlling delirium and agitation. Propranolol, a non-selective beta-adrenergic antagonist with good penetration of the blood-brain barrier, has not been investigated for this purpose.

MATERIALS AND METHODS: We retrospectively reviewed the medical records of all patients who were prescribed propranolol in our Medical Surgical ICU from January 1, 2010, to December 31, 2013. We recorded the sedation level and daily dose of sedatives, analgesics, and antipsychotics administered each day for 6 days after starting propranolol, and compared them to the day before starting propranolol.

RESULTS: Sixty-four patients met inclusion criteria. Thirty-eight episodes met exclusion criteria, leaving 27 patients (31 episodes). The administration of propranolol was associated with significant reductions in fentanyl equivalents (65%,

CONCLUSION: The use of propranolol was associated with a significant reduction in doses of sedatives and analgesia. Further studies are needed to determine whether propranolol may be a useful adjuvant for managing delirium and agitation in the ICU.

Keywords: adrenergic beta-antagonists; delirium; hypnotics and sedatives; intensive care unit; propranolol; psychomotor agitation

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