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Kulkarni BSN, Bajwa H, Chandrashekhar M, et al. CT- and MRI-based gross target volume comparison in vestibular schwannomas. Rep Pract Oncol Radiother. 2017;22(3):201-208doi: 10.1016/j.rpor.2017.02.002.
Kulkarni, B. S. N., Bajwa, H., Chandrashekhar, M., Sharma, S. D., Singareddy, R., Gudipudi, D., Ahmad, S., Kumar, A., Sresty, N. V. N. M., & Raju, A. K. (2017). CT- and MRI-based gross target volume comparison in vestibular schwannomas. Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 22(3), 201-208. https://doi.org/10.1016/j.rpor.2017.02.002
Kulkarni, Bhudevi Soubhagya N, et al. "CT- and MRI-based gross target volume comparison in vestibular schwannomas." Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology vol. 22,3 (2017): 201-208. doi: https://doi.org/10.1016/j.rpor.2017.02.002
Kulkarni BSN, Bajwa H, Chandrashekhar M, Sharma SD, Singareddy R, Gudipudi D, Ahmad S, Kumar A, Sresty NVNM, Raju AK. CT- and MRI-based gross target volume comparison in vestibular schwannomas. Rep Pract Oncol Radiother. 2017 May-Jun;22(3):201-208. doi: 10.1016/j.rpor.2017.02.002. Epub 2017 Apr 22. PMID: 28461783; PMCID: PMC5403802.
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Rep Pract Oncol Radiother. 2017 May-Jun;22(3):201-208. doi: 10.1016/j.rpor.2017.02.002. Epub 2017 Apr 22.

CT- and MRI-based gross target volume comparison in vestibular schwannomas.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

Bhudevi Soubhagya N Kulkarni, Harjot Bajwa, Mukka Chandrashekhar, Sunil Dutt Sharma, Rohith Singareddy, Dileep Gudipudi, Shabbir Ahmad, Alok Kumar, N V N Madusudan Sresty, Alluri Krishnam Raju

Affiliations

  1. Basavatarakam Indo American Cancer Hospital and Research Center, Hyderabad 500035, Telangana, India.
  2. Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500 085, Telangana, India.
  3. Radiological Physics & Advisory Division, Bhabha Atomic Research Centre, CTCRS, Anushaktinagar, Mumbai 400094, India.
  4. Clearmedi Healthcare Pvt. Ltd., Kolkata Area, India.

PMID: 28461783 PMCID: PMC5403802 DOI: 10.1016/j.rpor.2017.02.002

Abstract

AIM: This study represents an enumeration and comparison of gross target volumes (GTV) as delineated independently on contrast-enhanced computed tomography (CT) and T1 and T2 weighted magnetic resonance imaging (MRI) in vestibular schwannomas (VS).

BACKGROUND: Multiple imaging in radiotherapy improves target localization.

METHODS AND MATERIALS: 42 patients of VS were considered for this prospective study with one patient showing bilateral tumor. The GTV was delineated separately on CT and MRI. Difference in volumes were estimated individually for all the 43 lesions and similarity was studied between CT and T1 and T2 weighted MRI.

RESULTS: The male to female ratio for VS was found to be 1:1.3. The tumor was right sided in 34.9% and left sided in 65.1%. Tumor volumes (TV) on CT image sets were ranging from 0.251 cc to 27.27 cc. The TV for CT, MRI T1 and T2 weighted were 5.15 ± 5.2 cc, 5.8 ± 6.23 cc, and 5.9 ± 6.13 cc, respectively. Compared to MRI, CT underestimated the volumes. The mean dice coefficient between CT versus T1 and CT versus T2 was estimated to be 68.85 ± 18.3 and 66.68 ± 20.3, respectively. The percentage of volume difference between CT and MRI (%VD: mean ± SD for T1; 28.84 ± 15.0, T2; 35.74 ± 16.3) and volume error (%VE: T1; 18.77 ± 10.1, T2; 23.17 ± 13.93) were found to be significant, taking the CT volumes as the baseline.

CONCLUSIONS: MRI with multiple sequences should be incorporated for tumor volume delineation and they provide a clear boundary between the tumor and normal tissue with critical structures nearby.

Keywords: Computed tomography (CT); Magnetic resonance imaging (MRI); T1 weighted and T2 weighted; Vestibular schwannomas (VS)

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