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Lee M, Kim J, Jo DS. Effects of clarithromycin treatment in scrub typhus in children: comparison with chloramphenicol and azithromycin. Korean J Pediatr. 2017;60(4):124-127doi: 10.3345/kjp.2017.60.4.124.
Lee, M., Kim, J., & Jo, D. S. (2017). Effects of clarithromycin treatment in scrub typhus in children: comparison with chloramphenicol and azithromycin. Korean journal of pediatrics, 60(4), 124-127. https://doi.org/10.3345/kjp.2017.60.4.124
Lee, Min, et al. "Effects of clarithromycin treatment in scrub typhus in children: comparison with chloramphenicol and azithromycin." Korean journal of pediatrics vol. 60,4 (2017): 124-127. doi: https://doi.org/10.3345/kjp.2017.60.4.124
Lee M, Kim J, Jo DS. Effects of clarithromycin treatment in scrub typhus in children: comparison with chloramphenicol and azithromycin. Korean J Pediatr. 2017 Apr;60(4):124-127. doi: 10.3345/kjp.2017.60.4.124. Epub 2017 Apr 25. PMID: 28461826; PMCID: PMC5410619.
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Korean J Pediatr. 2017 Apr;60(4):124-127. doi: 10.3345/kjp.2017.60.4.124. Epub 2017 Apr 25.

Effects of clarithromycin treatment in scrub typhus in children: comparison with chloramphenicol and azithromycin.

Korean journal of pediatrics

Min Lee, June Kim, Dae Sun Jo

Affiliations

  1. Department of Pediatrics, Chonbuk National University Children's Hospital, Jeonju, Korea.

PMID: 28461826 PMCID: PMC5410619 DOI: 10.3345/kjp.2017.60.4.124

Abstract

PURPOSE: Chloramphenicol and tetracycline are not recommended for treating scrub typhus in pediatric patients because of potential side effects, such as aplastic anemia or tooth discoloration. While clarithromycin has recently been used in adults, few reports have been published on its effects in pediatric patients. We report the clinical profiles of pediatric scrub typhus and the effects of clarithromycin on scrub typhus in children.

METHODS: We retrospectively analyzed medical records of 56 children with scrub typhus who were admitted between 2004 and 2013 to Chonbuk National University Hospital, Jeonju, Korea. Cases were divided into 3 groups based on thetreatment drug (chloramphenicol, azithromycin, and clarithromycin). We compared their clinical manifestations and laboratory findings.

RESULTS: All patients exhibited fever and rash. Other common clinical manifestations were eschars (66%), lymphadenopathy (48%), upper respiratory symptoms (42%), abdominal pain (32%), and hepatosplenomegaly (14%). Elevated levels of C-reactive protein, erythrocyte sedimentation rates, aspartate transaminase, and alanine transaminase were detected in 95%, 96%, 84%, and 77% of patients, respectively. Additionally, decreased platelet and white blood cell levels were observed in 43% and 36% of patients, respectively. There were no statistical differences between the treatment groups in mean age (

CONCLUSION: Clarithromycin was as effective as chloramphenicol and azithromycin in pediatric scrub typhus patients and may be used as a first-line treatment drug.

Keywords: Azithromycin; Chloramphenicol; Clarithromycin; Pediatric patients; Scrub typhus

Conflict of interest statement

Conflict of interest: No potential conflict of interest relevant to this article was reported.

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