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Yun Y, Son J, Kim K, et al. Effectiveness and safety of combination treatment of herbal medicines and oral antihistamines for atopic dermatitis: a retrospective chart review. Integr Med Res. 2017;6(1):19-25doi: 10.1016/j.imr.2017.01.002.
Yun, Y., Son, J., Kim, K., Jang, B. H., Choi, I., & Ko, S. G. (2017). Effectiveness and safety of combination treatment of herbal medicines and oral antihistamines for atopic dermatitis: a retrospective chart review. Integrative medicine research, 6(1), 19-25. https://doi.org/10.1016/j.imr.2017.01.002
Yun, Younghee, et al. "Effectiveness and safety of combination treatment of herbal medicines and oral antihistamines for atopic dermatitis: a retrospective chart review." Integrative medicine research vol. 6,1 (2017): 19-25. doi: https://doi.org/10.1016/j.imr.2017.01.002
Yun Y, Son J, Kim K, Jang BH, Choi I, Ko SG. Effectiveness and safety of combination treatment of herbal medicines and oral antihistamines for atopic dermatitis: a retrospective chart review. Integr Med Res. 2017 Mar;6(1):19-25. doi: 10.1016/j.imr.2017.01.002. Epub 2017 Jan 17. PMID: 28462140; PMCID: PMC5395680.
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Integr Med Res. 2017 Mar;6(1):19-25. doi: 10.1016/j.imr.2017.01.002. Epub 2017 Jan 17.

Effectiveness and safety of combination treatment of herbal medicines and oral antihistamines for atopic dermatitis: a retrospective chart review.

Integrative medicine research

Younghee Yun, Jaewoong Son, Kyuseok Kim, Bo-Hyeong Jang, Inhwa Choi, Seong-Gyu Ko

Affiliations

  1. Department of Ophthalmology, Otorhinolaryngology and Dermatology of Korean Medicine, Kyung Hee University, Seoul, Korea.
  2. Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Korea.

PMID: 28462140 PMCID: PMC5395680 DOI: 10.1016/j.imr.2017.01.002

Abstract

BACKGROUND: Patients with atopic dermatitis (AD) exhibit various symptoms, especially itching. Recently, herbal medicines (HMs) are being used in combination with antihistamines for the treatment of AD in Korea. While oral antihistamines can alleviate itching, HMs appear to exert anti-inflammatory effects with minimal side effects. However, there is little evidence regarding the effectiveness and safety of using HMs in combination with antihistamines for AD.

METHODS: To observe the effectiveness and safety of combination treatment with HMs and antihistamines, we performed a retrospective chart review of inpatients with AD who received this combination treatment for at least 7 days in a hospital.

RESULTS: Of 163 inpatients, 40 met the inclusion criteria. All patients received HMs three times, and one or two antihistamines, a day after HM intake. A large proportion of patients received first-generation antihistamines. HMs comprised a mixture of an average of 20.69 different herbs in decoction. The mean total, objective, and subjective SCORing Atopic Dermatitis scores showed a significant decrease after combination treatment. Changes in the mean levels of aspartate transaminase, alanine transaminase, blood urea nitrogen, and creatinine were not statistically significant among treatments. There were no adverse events of pseudoaldosteronism or interstitial pneumonia.

CONCLUSION: We observed that the short-term use of HMs in combination with oral antihistamines was safe and effective, with a low risk of adverse reactions. This study was limited by its retrospective design, and prospective studies with long-term follow-up periods are warranted to further elucidate the safety of this combination treatment for AD.

Keywords: antihistamines; atopic dermatitis; herbal medicine; herb–drug interactions; retrospective chart review

References

  1. J Eur Acad Dermatol Venereol. 2010 Nov;24(11):1249-60 - PubMed
  2. Dermatol Res Pract. 2016;2016:4060673 - PubMed
  3. J Altern Complement Med. 2012 Jun;18(6):576-82 - PubMed
  4. J Eur Acad Dermatol Venereol. 2014 May;28 Suppl 3:9-15 - PubMed
  5. Food Chem Toxicol. 2015 Oct;84:47-54 - PubMed
  6. J Allergy Clin Immunol. 2011 Dec;128(6):1139-1150.e4 - PubMed
  7. J Allergy Clin Immunol. 1999 Jan;103(1 Pt 1):125-38 - PubMed
  8. Mediators Inflamm. 2014;2014:752103 - PubMed
  9. Int J Clin Pharmacol Ther. 2007 Nov;45(11):583-91 - PubMed
  10. Semin Cutan Med Surg. 2011 Jun;30(2):71-86 - PubMed
  11. Complement Ther Med. 2013 Jun;21(3):200-6 - PubMed
  12. Eur Respir J. 1996 Dec;9(12 ):2691-6 - PubMed
  13. Adv Wound Care (New Rochelle). 2013 Oct;2(8):448-455 - PubMed
  14. J Gastroenterol Hepatol. 2001 Jan;16(1):115-7 - PubMed
  15. BMJ. 2000 Apr 29;320(7243):1184-6 - PubMed
  16. Phytomedicine. 2003;10 Suppl 4:31-7 - PubMed
  17. J Burn Care Res. 2012 Jul-Aug;33(4):e195-200 - PubMed
  18. Ann Nutr Metab. 2015;66 Suppl 1:8-16 - PubMed
  19. BMC Complement Altern Med. 2011 Aug 23;11:68 - PubMed
  20. Zhongguo Zhong Yao Za Zhi. 2013 Apr;38(7):1095-7 - PubMed
  21. Allergy. 2009 Feb;64(2):265-75 - PubMed
  22. Dermatol Res Pract. 2009;2009:357046 - PubMed
  23. Am J Chin Med. 2008;36(1):115-23 - PubMed
  24. Int Arch Allergy Immunol. 2011;155(2):141-8 - PubMed
  25. J Ethnopharmacol. 2015 Jan 15;159:189-96 - PubMed
  26. Drugs. 2009;69(13):1777-98 - PubMed
  27. J Ethnopharmacol. 2015 Jan 15;159:253-6 - PubMed
  28. JAMA. 1968 Aug 12;205(7):492-6 - PubMed

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