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Leyssens K, Mortelmans T, Menovsky T, et al. The Cushing Reflex: Oliguria as a Reflection of an Elevated Intracranial Pressure. Case Rep Nephrol. 2017;2017:2582509doi: 10.1155/2017/2582509.
Leyssens, K., Mortelmans, T., Menovsky, T., Abramowicz, D., Twickler, M. T. B., & Van Gaal, L. (2017). The Cushing Reflex: Oliguria as a Reflection of an Elevated Intracranial Pressure. Case reports in nephrology, 20172582509. https://doi.org/10.1155/2017/2582509
Leyssens, K, et al. "The Cushing Reflex: Oliguria as a Reflection of an Elevated Intracranial Pressure." Case reports in nephrology vol. 2017 (2017): 2582509. doi: https://doi.org/10.1155/2017/2582509
Leyssens K, Mortelmans T, Menovsky T, Abramowicz D, Twickler MTB, Van Gaal L. The Cushing Reflex: Oliguria as a Reflection of an Elevated Intracranial Pressure. Case Rep Nephrol. 2017;2017:2582509. doi: 10.1155/2017/2582509. Epub 2017 May 15. PMID: 28589048; PMCID: PMC5447257.
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Case Rep Nephrol. 2017;2017:2582509. doi: 10.1155/2017/2582509. Epub 2017 May 15.

The Cushing Reflex: Oliguria as a Reflection of an Elevated Intracranial Pressure.

Case reports in nephrology

K Leyssens, T Mortelmans, T Menovsky, D Abramowicz, Marcel Th B Twickler, L Van Gaal

Affiliations

  1. Department of Internal Medicine, University of Antwerp, Antwerp, Belgium.
  2. Faculty of Medicine, University of Antwerp, Antwerp, Belgium.
  3. Department of Neurosurgery, Antwerp University Hospital, Edegem, Antwerp, Belgium.
  4. Department of Nephrology, Antwerp University Hospital, Edegem, Antwerp, Belgium.
  5. Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Edegem, Antwerp, Belgium.

PMID: 28589048 PMCID: PMC5447257 DOI: 10.1155/2017/2582509

Abstract

Oliguria is one of the clinical hallmarks of renal failure. The broad differential diagnosis is well known, but a rare cause of oliguria is intracranial hypertension (ICH). The actual knowledge to explain this relationship is scarce. Almost all literature is about animals where authors describe the Cushing reflex in response to ICH. We hypothesize that the Cushing reflex is translated towards the sympathetic nervous system and renin-angiotensin-aldosterone system with a subsequent reduction in medullary blood flow and oliguria. Recently, we were confronted with a patient who had complicated pituitary surgery and displayed multiple times an oliguria while he developed ICH.

References

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  3. Clin Sci. 1969 Feb;36(1):99-108 - PubMed

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