Display options
Cite
Dabiri Satri S, Gharibi R, Nejadian F, et al. Intratympanic Injection of Dexamethasone and Electrocochleographic Data in Cases of Definite One Sided Refractory Meniere's Disease. Iran J Otorhinolaryngol. 2017;29(92):121-125
Dabiri Satri, S., Gharibi, R., Nejadian, F., Yazdani, N., Hoseinabadi, R., Rezazadeh, N., Firouzifar, M. R., & Babaei, S. (2017). Intratympanic Injection of Dexamethasone and Electrocochleographic Data in Cases of Definite One Sided Refractory Meniere's Disease. Iranian journal of otorhinolaryngology, 29(92), 121-125.
Dabiri Satri, Sasan, et al. "Intratympanic Injection of Dexamethasone and Electrocochleographic Data in Cases of Definite One Sided Refractory Meniere's Disease." Iranian journal of otorhinolaryngology vol. 29,92 (2017): 121-125.
Dabiri Satri S, Gharibi R, Nejadian F, Yazdani N, Hoseinabadi R, Rezazadeh N, Firouzifar MR, Babaei S. Intratympanic Injection of Dexamethasone and Electrocochleographic Data in Cases of Definite One Sided Refractory Meniere's Disease. Iran J Otorhinolaryngol. 2017 May;29(92):121-125. PMID: 28589104; PMCID: PMC5448025.
Copy Download .nbib Format: NLM
Share it on

Iran J Otorhinolaryngol. 2017 May;29(92):121-125.

Intratympanic Injection of Dexamethasone and Electrocochleographic Data in Cases of Definite One Sided Refractory Meniere's Disease.

Iranian journal of otorhinolaryngology

Sasan Dabiri Satri, Reza Gharibi, Farzaneh Nejadian, Nasrin Yazdani, Reza Hoseinabadi, Nima Rezazadeh, Mohammad Reza Firouzifar, Saeed Babaei

Affiliations

  1. Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  2. Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
  3. Department of Audiology, University of Social Welfare and Rehabilitation, Tehran, Iran.

PMID: 28589104 PMCID: PMC5448025

Abstract

INTRODUCTION: Meniere's disease (MD) is a disease of the inner ear that presents itself with repeated episodes of vertigo (96.2%), tinnitus (91.1%), and sensorineural hearing loss (87.7 %). In this article we sought to assess the effects of intratympanic (IT) injections of dexamethasone on definite cases of MD using electrocochleography (ECOG).

MATERIALS AND METHODS: In this hospital-based case series in 36 patients, we measured audiometric values and ECOG in all patients before, 1 month and 6 months after 4-mg/mL IT injections of dexamethasone.

RESULTS: Four patients (11%) had improved hearing following the intervention. No difference in pure tone audiometry (PTA) was observed following IT injections (P=0.492), while speech discrimination score (SDS) was significantly improved (P=0.008). There was a significant improvement in vertigo 1 month after IT injections (P<0.001), although this effect did not last for 6 months. No significant change in ECOG was observed between before and after treatment (P=0.052).

CONCLUSION: IT dexamethasone injections can improve vertigo in definite cases of MD, although it seems that the effect is only temporary.

Keywords: Dexamethasone; EcochG; Meniere’s disease

References

  1. Am J Audiol. 1999 Jun;8(1):21-8 - PubMed
  2. Otolaryngol Head Neck Surg. 2000 Apr;122(4):521-8 - PubMed
  3. Am J Otol. 1998 Mar;19(2):196-201 - PubMed
  4. Otol Neurotol. 2010 Jan;31(1):162-7 - PubMed
  5. Acta Otolaryngol. 2013 Nov;133(11):1158-64 - PubMed
  6. Otolaryngol Clin North Am. 2004 Oct;37(5):955-72, v - PubMed
  7. Acta Otorrinolaringol Esp. 2012 Nov-Dec;63(6):421-8 - PubMed
  8. Laryngoscope. 2015 May;125(5):1183-8 - PubMed
  9. Laryngoscope. 2001 Dec;111(12):2100-4 - PubMed

Publication Types