Display options
Cite
Flahault A, Couvineau P, Alvear-Perez R, et al. Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders. Front Endocrinol (Lausanne). 2017;8:120doi: 10.3389/fendo.2017.00120.
Flahault, A., Couvineau, P., Alvear-Perez, R., Iturrioz, X., & Llorens-Cortes, C. (2017). Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders. Frontiers in endocrinology, 8120. https://doi.org/10.3389/fendo.2017.00120
Flahault, Adrien, et al. "Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders." Frontiers in endocrinology vol. 8 (2017): 120. doi: https://doi.org/10.3389/fendo.2017.00120
Flahault A, Couvineau P, Alvear-Perez R, Iturrioz X, Llorens-Cortes C. Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders. Front Endocrinol (Lausanne). 2017 May 31;8:120. doi: 10.3389/fendo.2017.00120. eCollection 2017. PMID: 28620355; PMCID: PMC5450005.
Copy Download .nbib Format: NLM
Share it on

Front Endocrinol (Lausanne). 2017 May 31;8:120. doi: 10.3389/fendo.2017.00120. eCollection 2017.

Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders.

Frontiers in endocrinology

Adrien Flahault, Pierre Couvineau, Rodrigo Alvear-Perez, Xavier Iturrioz, Catherine Llorens-Cortes

Affiliations

  1. Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, Center for Interdisciplinary Research in Biology (CIRB), INSERM, U1050/CNRS, UMR 7241, College de France, Paris, France.

PMID: 28620355 PMCID: PMC5450005 DOI: 10.3389/fendo.2017.00120

Abstract

Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling body fluid homeostasis and cardiovascular functions. In animal models, experimental data demonstrate that intracerebroventricular injection of apelin into lactating rats inhibits the phasic electrical activity of arginine vasopressin (AVP) neurons, reduces plasma AVP levels, and increases aqueous diuresis. In the kidney, apelin increases diuresis by increasing the renal microcirculation and by counteracting the antidiuretic effect of AVP at the tubular level. Moreover, after water deprivation or salt loading, in humans and in rodents, AVP and apelin are conversely regulated to facilitate systemic AVP release and to avoid additional water loss from the kidney. Furthermore, apelin and vasopressin secretion are significantly altered in various water metabolism disorders including hyponatremia and polyuria-polydipsia syndrome. Since the

Keywords: G protein-coupled receptor; apelin; apelin receptor; apelin water metabolism disorders; diuresis; metabolically stable apelin analogs; osmolality; vasopressin

References

  1. Neuroendocrinology. 2000 Dec;72(6):400-7 - PubMed
  2. Hypertension. 2015 Apr;65(4):834-40 - PubMed
  3. J Med Chem. 2015 Mar 12;58(5):2431-40 - PubMed
  4. Biopolymers. 2014 Jul;102(4):297-303 - PubMed
  5. Cell Signal. 2012 May;24(5):991-1001 - PubMed
  6. Neuroscience. 2002;113(3):653-62 - PubMed
  7. ChemMedChem. 2016 Aug 25;:null - PubMed
  8. Gene. 1993 Dec 22;136(1-2):355-60 - PubMed
  9. Congest Heart Fail. 2005 Sep-Oct;11(5):274-7 - PubMed
  10. Br J Pharmacol. 2013 Mar;168(5):1104-17 - PubMed
  11. Biochem Biophys Res Commun. 1998 Oct 20;251(2):471-6 - PubMed
  12. Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1289-99 - PubMed
  13. Endocrinology. 2004 Sep;145(9):4392-400 - PubMed
  14. J Clin Endocrinol Metab. 2016 May;101(5):1917-23 - PubMed
  15. Hypertension. 2016 Aug;68(2):365-77 - PubMed
  16. Endocrinology. 1998 Nov;139(11):4701-7 - PubMed
  17. PLoS One. 2014 Feb 05;9(2):e87421 - PubMed
  18. Hypertens Res. 2011 Jun;34(6):701-6 - PubMed
  19. Endocrinology. 2011 Sep;152(9):3492-503 - PubMed
  20. J Biol Chem. 2015 Jul 24;290(30):18261-8 - PubMed
  21. J Biol Chem. 2006 Jul 7;281(27):18317-26 - PubMed
  22. J Clin Endocrinol Metab. 2015 Jun;100(6):2268-74 - PubMed
  23. J Neurol Sci. 1985 Jul;69(3):291-9 - PubMed
  24. N Engl J Med. 2007 May 17;356(20):2064-72 - PubMed
  25. J Neuroendocrinol. 2010 Apr;22(4):301-8 - PubMed
  26. J Neuroendocrinol. 1994 Dec;6(6):673-9 - PubMed
  27. Chembiochem. 2016 Aug 17;17 (16):1495-8 - PubMed
  28. Cell Physiol Biochem. 2011;27(6):757-68 - PubMed
  29. Circ Res. 2009 Jul 31;105(3):231-8 - PubMed
  30. Science. 1980 Jan 25;207(4429):373-8 - PubMed
  31. J Biol Chem. 2010 Oct 15;285(42):32627-37 - PubMed
  32. Circ Res. 2002 Sep 6;91(5):434-40 - PubMed
  33. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11968-73 - PubMed
  34. Heart Fail Rev. 2015 Jul;20(4):493-503 - PubMed
  35. J Clin Invest. 1997 Mar 15;99(6):1399-405 - PubMed
  36. Biochemistry. 2009 Jan 27;48(3):537-48 - PubMed
  37. J Neuroendocrinol. 1998 Dec;10(12):881-95 - PubMed
  38. Mech Dev. 1999 Jun;84(1-2):199-203 - PubMed
  39. J Neurovirol. 2000 May;6 Suppl 1:S61-9 - PubMed
  40. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1013-7 - PubMed
  41. Drug Discov Today. 2015 Jan;20(1):122-8 - PubMed
  42. J Biol Chem. 1986 Oct 5;261(28):12956-9 - PubMed
  43. J Clin Endocrinol Metab. 2011 Apr;96(4):1046-52 - PubMed
  44. J Clin Endocrinol Metab. 2013 May;98(5):2084-9 - PubMed
  45. FEBS Open Bio. 2013 Aug 09;3:328-33 - PubMed
  46. Kidney Int. 2008 Aug;74(4):486-94 - PubMed
  47. Proc R Soc Lond B Biol Sci. 1977 Apr;196(1125):367-84 - PubMed
  48. Circ Res. 1977 May;40(5 Suppl 1):I110-7 - PubMed
  49. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10464-9 - PubMed
  50. Biochim Biophys Acta. 1999 Oct 13;1452(1):25-35 - PubMed
  51. ChemMedChem. 2012 Feb 6;7(2):318-25 - PubMed
  52. J Med Chem. 2016 Apr 14;59(7):2962-72 - PubMed
  53. Virology. 2003 Mar 1;307(1):22-36 - PubMed
  54. FASEB J. 2017 Feb;31(2):687-700 - PubMed
  55. J Neurochem. 2001 May;77(4):1085-96 - PubMed
  56. Bioorg Khim. 2012 Jan-Feb;38(1):40-51 - PubMed
  57. Brain Res. 1992 Jul 24;586(2):289-94 - PubMed
  58. Biochem Biophys Res Commun. 2010 Apr 30;395(2):185-9 - PubMed
  59. Biochemistry. 2003 Sep 2;42(34):10163-8 - PubMed
  60. Arch Intern Med. 1996 Sep 9;156(16):1814-20 - PubMed
  61. N Engl J Med. 1984 Sep 20;311(12):753-9 - PubMed
  62. Brain Res. 1994 Aug 1;652(2):207-15 - PubMed
  63. J Am Soc Nephrol. 2008 May;19(5):1015-24 - PubMed
  64. Eur J Clin Nutr. 2010 Feb;64(2):115-23 - PubMed
  65. J Biol Chem. 2017 Feb 3;292(5):1925-1933 - PubMed
  66. J Biol Chem. 2002 Apr 26;277(17):14838-43 - PubMed
  67. J Neuroendocrinol. 2003 Jul;15(7):661-6 - PubMed
  68. Clin Exp Pharmacol Physiol. 1996 Feb;23(2):183-91 - PubMed
  69. Peptides. 2012 Nov;38(1):181-8 - PubMed
  70. Endocrinology. 2014 Nov;155(11):4483-93 - PubMed
  71. Circ Res. 2008 Aug 15;103(4):432-40 - PubMed
  72. Int J Mol Med. 2008 Oct;22(4):547-52 - PubMed
  73. Acta Biochim Biophys Sin (Shanghai). 2008 Apr;40(4):311-8 - PubMed
  74. J Neurosci. 1998 Mar 1;18(5):1879-85 - PubMed
  75. Fed Proc. 1977 May;36(6):1848-52 - PubMed
  76. Am J Cardiol. 1986 Aug 1;58(3):295-9 - PubMed
  77. J Neurochem. 2004 Sep;90(6):1290-301 - PubMed
  78. J Endocrinol. 2009 Sep;202(3):453-62 - PubMed
  79. Biochim Biophys Acta. 2000 Jun 21;1492(1):72-80 - PubMed
  80. Cell Signal. 2014 Jul;26(7):1549-59 - PubMed
  81. FASEB J. 2015 Jan;29(1):314-22 - PubMed
  82. Am J Physiol. 1992 Feb;262(2 Pt 2):R310-7 - PubMed
  83. J Neurochem. 2000 Jan;74(1):34-41 - PubMed
  84. Peptides. 1983 Mar-Apr;4(2):165-70 - PubMed
  85. Biochim Biophys Acta. 2001 Apr 23;1538(2-3):162-71 - PubMed
  86. Peptides. 2012 Jan;33(1):139-48 - PubMed
  87. J Clin Endocrinol Metab. 2009 Jan;94(1):123-9 - PubMed
  88. J Neurochem. 2003 Mar;84(5):1162-72 - PubMed
  89. Trends Endocrinol Metab. 2008 Mar;19(2):43-9 - PubMed
  90. Acta Endocrinol (Copenh). 1992 Apr;126(4):357-62 - PubMed
  91. Physiol Rev. 2001 Apr;81(2):629-83 - PubMed
  92. Nat Rev Endocrinol. 2016 Mar;12(3):168-76 - PubMed
  93. J Am Soc Nephrol. 2014 Oct;25(10):2376-83 - PubMed
  94. Endocrinology. 2005 Jan;146(1):231-6 - PubMed
  95. Neurobiol Aging. 2009 Oct;30(10):1677-92 - PubMed
  96. Curr Pharm Des. 2012;18(6):789-98 - PubMed
  97. Brain Res. 1985 Sep 2;342(1):45-53 - PubMed
  98. Circulation. 2010 Apr 27;121(16):1818-27 - PubMed
  99. Virology. 2003 Dec 5;317(1):84-94 - PubMed
  100. J Biol Chem. 2014 Aug 29;289(35):24599-610 - PubMed
  101. Regul Pept. 2005 Mar 30;126(3):233-40 - PubMed
  102. Endocrinology. 1992 Jul;131(1):533-5 - PubMed
  103. Neurosci Lett. 2002 Jul 26;327(3):193-7 - PubMed
  104. J Biol Chem. 2000 Jul 14;275(28):21061-7 - PubMed
  105. Biochem Biophys Res Commun. 2002 Jan 11;290(1):539-45 - PubMed
  106. J Clin Invest. 2008 Oct;118(10):3343-54 - PubMed
  107. Org Biomol Chem. 2017 Jan 4;15(2):449-458 - PubMed

Publication Types