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Naydenov E, Minkin K, Penkov M, et al. Infrared Thermography in Surgery of Newly Diagnosed Glioblastoma Multiforme: A Technical Case Report. Case Rep Oncol. 2017;10(1):350-355doi: 10.1159/000470832.
Naydenov, E., Minkin, K., Penkov, M., Nachev, S., & Stummer, W. (2017). Infrared Thermography in Surgery of Newly Diagnosed Glioblastoma Multiforme: A Technical Case Report. Case reports in oncology, 10(1), 350-355. https://doi.org/10.1159/000470832
Naydenov, Emanuil, et al. "Infrared Thermography in Surgery of Newly Diagnosed Glioblastoma Multiforme: A Technical Case Report." Case reports in oncology vol. 10,1 (2017): 350-355. doi: https://doi.org/10.1159/000470832
Naydenov E, Minkin K, Penkov M, Nachev S, Stummer W. Infrared Thermography in Surgery of Newly Diagnosed Glioblastoma Multiforme: A Technical Case Report. Case Rep Oncol. 2017 Apr 18;10(1):350-355. doi: 10.1159/000470832. eCollection 2017. PMID: 28559818; PMCID: PMC5436014.
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Case Rep Oncol. 2017 Apr 18;10(1):350-355. doi: 10.1159/000470832. eCollection 2017.

Infrared Thermography in Surgery of Newly Diagnosed Glioblastoma Multiforme: A Technical Case Report.

Case reports in oncology

Emanuil Naydenov, Krasimir Minkin, Marin Penkov, Sevdalin Nachev, Walter Stummer

Affiliations

  1. aDepartment of Neurosurgery, University Hospital "St. Ivan Rilski", Sofia, Bulgaria.
  2. bDepartment of Radiology, University Hospital "St. Ivan Rilski", Sofia, Bulgaria.
  3. cLaboratory of Neuropathology, University Hospital "St. Ivan Rilski", Sofia, Bulgaria.
  4. dDepartment of Neurosurgery, University of Münster, Münster, Germany.

PMID: 28559818 PMCID: PMC5436014 DOI: 10.1159/000470832

Abstract

Infrared thermography (IRT) is a real-time non-contact diagnostic tool with a broad potential for neurosurgical applications. Here we describe the intraoperative use of this technique in a single patient with newly diagnosed glioblastoma multiforme (GBM). An 86-year-old female was admitted in the clinic with a 2-month history of slowly progressing left-sided paresis. Neuroimaging studies demonstrated an irregular space-occupying process consistent with a malignant glioma in the right fronto-temporo-insular region. An elective surgical intervention was performed by using 5-aminolevulinic acid fluorescence (BLUE 400, OPMI) and intraoperative IRT brain mapping (LWIR, 1.25 mRad IFOV, 0.05°C NETD). After dura opening, the cerebral surface appeared inconspicuous. However, IRT revealed a significantly colder area (Δt° 1.01°C), well corresponding to the cortical epicenter of the lesion. The underlying tumor was partially excised and the histological result was GBM. Intraoperative IRT seems to be a useful technique for subcortical convexity brain tumor localization. Further studies with a large number of patients are needed to prove the reliability of this method in GBM surgery.

Keywords: 5-aminolevulinic acid; Glioblastoma multiforme; Infrared thermography; Neuroimaging

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