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Rietman AB, Oostenbrink R, Bongers S, et al. Motor problems in children with neurofibromatosis type 1. J Neurodev Disord. 2017;9:19doi: 10.1186/s11689-017-9198-5.
Rietman, A. B., Oostenbrink, R., Bongers, S., Gaukema, E., van Abeelen, S., Hendriksen, J. G., Looman, C. W. N., de Nijs, P. F. A., & de Wit, M. C. (2017). Motor problems in children with neurofibromatosis type 1. Journal of neurodevelopmental disorders, 919. https://doi.org/10.1186/s11689-017-9198-5
Rietman, André B, et al. "Motor problems in children with neurofibromatosis type 1." Journal of neurodevelopmental disorders vol. 9 (2017): 19. doi: https://doi.org/10.1186/s11689-017-9198-5
Rietman AB, Oostenbrink R, Bongers S, Gaukema E, van Abeelen S, Hendriksen JG, Looman CWN, de Nijs PFA, de Wit MC. Motor problems in children with neurofibromatosis type 1. J Neurodev Disord. 2017 May 19;9:19. doi: 10.1186/s11689-017-9198-5. eCollection 2017. PMID: 28529667; PMCID: PMC5437487.
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J Neurodev Disord. 2017 May 19;9:19. doi: 10.1186/s11689-017-9198-5. eCollection 2017.

Motor problems in children with neurofibromatosis type 1.

Journal of neurodevelopmental disorders

André B Rietman, Rianne Oostenbrink, Sanne Bongers, Eddy Gaukema, Sandra van Abeelen, Jos G Hendriksen, Caspar W N Looman, Pieter F A de Nijs, Marie-Claire de Wit

Affiliations

  1. Department of Child and Adolescent Psychiatry/Psychology, ENCORE NF1 Expertise Centre for Neurodevelopmental Disorders, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands.
  2. Department of Child and Adolescent Psychiatry/Psychology, Sophia Children's Hospital, Room Sp 2478, P.O. Box 2060, 3000 CB Rotterdam, The Netherlands.
  3. Department of General Paediatrics, ENCORE NF1, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands.
  4. Kempenhaeghe Centre for neurological learning disabilities, Heeze, The Netherlands.
  5. Department of Public Health, Erasmus Medical Centre, Rotterdam, The Netherlands.
  6. Department of Paediatric Neurology, ENCORE NF1, Erasmus Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands.

PMID: 28529667 PMCID: PMC5437487 DOI: 10.1186/s11689-017-9198-5

Abstract

BACKGROUND: Children with the neurogenetic disorder neurofibromatosis type 1 (NF1) often have problems with learning and behaviour. In both parent reports and neuropsychological assessment, motor problems are reported in approximately one third to one half of the children with NF1. Studies using broad motor performance test batteries with relatively large groups of children with NF1 are limited. The aim of this cross-sectional observational study was to describe the severity of motor problems in children with NF1 and to explore the predictive value of demographics, intelligence, and behavioural problems.

METHODS: From 2002 to 2014, 69 children with NF1, aged 4 to 16 years (age = 9.5 ± 2.8 years; 29 girls) had a motor, psychological, and neurological evaluation in an NF1 expertise centre. Data were collected about (1) motor performance (M-ABC: Movement Assessment Battery for Children), (2) intelligence, and (3) emotional and behavioural problems as rated by parents.

RESULTS: Sixty-one percent of these children scored within the clinical range of the M-ABC. In ordinal logistic regression analyses, motor problems were associated with symptoms of attention-deficit/hyperactivity disorder (ADHD), symptoms of autism spectrum disorder (ASD), and externalising behavioural problems. Motor outcome was not predicted by age, intelligence, scoliosis, hypotonia, nor hypermobility.

CONCLUSIONS: Motor problems are among the most common comorbid developmental problems in children with NF1, and these problems do not diminish with age. Because of their impact on daily functioning, motor problems need to be specifically addressed in diagnosis, follow-up, and treatment of NF1.

Keywords: DCD; Emotional and behavioural problems; Intelligence; Motor problems; Neurofibromatosis type 1

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